2 documents found, page 1 of 1
Peripheral antinociceptive action of mangiferin in mouse models of experimental...
Lopes, Synara C.; Silva, Ana Virgínia Lima da; Arruda, Bruno Rodrigues; Morais, Talita Cavalcante; Rios, Jeison Barros Rioshis study aimed to assess the possible systemic antinociceptive activity of mangiferin and to clarify the un- derlying mechanism, using the acute models of chemical (acetic acid, formalin, and capsaicin) and thermal (hot-plate and tail- fl ick) nociception in mice. Mangiferin at oral doses of 10 to 100 mg/kg evidenced signif- icant antinociception against chemogenic pain in the test models of acetic acid-induce...
Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice in...
Morais, Talita Cavalcante; Lopes, Synara Cavalcante; Carvalho, Karine Maria Martins Bezerra; Arruda, Bruno Rodrigues; Souza, Francisco Thiago Correia deAIM: To investigate the effects of mangiferin on gas - trointestinal transit (GIT) in normal and constipated mice, together with the possible mechanism. METHODS: Intragastrically-administered charcoal mea was used to measure GIT in overnight starved Swiss mice. In the first experiments, mangiferin (3 mg/kg, 10 mg/kg, 30 mg/kg, and 100 mg/kg, po ) or tegaserod (1 mg/kg, ip ) were administered 30 min before the c...