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Cost-Effective Trap qPCR Approach to Evaluate Telomerase Activity: an Important...

Pinto, Thalyta Nery Carvalho; Fernandes, Juliana Ruiz; Arruda, Liã Barbara; Duarte, Alberto José da Silva; Benard, Gil

OBJECTIVES: Telomeres are a terminal ‘‘DNA cap’’ that prevent chromosomal fusion and degradation. However, aging is inherent to life, and so is the loss of terminal sequences. Telomerase is a specialized reverse transcriptase encoded by self-splicing introns that counteract chromosome erosion. Telomerase activity is observed during early embryonic development, but after the blastocyst stage, the expression of t...

Date: 2021   |   Origin: Oasisbr
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