3 documents found, page 1 of 1
Prognostic Significance of Age Within the Adolescent and Young Adult Acute Isch...
Lu, VM; Luther, EM; Silva, MA; Elarjani, T; Abdelsalam, A; Maier, I; Al Kasab, S; Jabbour, PM; Kim, JT; Wolfe, SQ; Rai, AT; Psychogios, MNObjective: Although younger adults have been shown to have better functional outcomes after mechanical thrombectomy (MT) for acute ischemic stroke (AIS), the significance of this relationship in the adolescent and young adult (AYA) population is not well defined given its undefined rarity. Correspondingly, the goal of this study was to determine the prognostic significance of age in this specific demographic fo...
The novel 5-lipoxygenase inhibitor (ABT-761) attenuates cerebral vasospasm in a...
Barbosa, MD; Arthur, AS; Louis, RH; Polin, R; Kassel, N
The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a r...
Barbosa, MD; Arthur, AS; Louis, RH; MacDonald, T; Polin, RS; Gazak, C; Kassell, NFOBJECTIVE: Eicosanoids have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Leukotrienes, 5-hydroxyperoxyeicosatetraenoic acid, and 5-hydroxyeicosatetraenoic acid are part of this group of substances, resulting from the 5-lipoxygenase activity on arachidonic acid metabolism. This study examined the effects of ABT-761, a new 5-lipoxygenase inhibitor, on cerebral vas...