4 documents found, page 1 of 1
Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic f...
Stevanović-Silva, J; Beleza, J; Coxito, P; Pereira, S; Rocha, H; Gaspar, TB; Gärtner, F; Correia, R; Martins, MJ; Guimarães, T; Martins, S; Oliveira, PJBackground Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle disorders. Therefore, we investigated whether gestational exercise delays the development...
Physical exercise positively modulates DOX-induced hepatic oxidative stress, mi...
Santos-Alves, E; Rizo-Roca, D; Marques-Aleixo, I; Coxito, P; Martins, S; Guimarães, JT; Oliveira, PJ; Torrella, J; Magalhães, J; Ascensão, ADoxorubicin (DOX), a widely used and efficient antineoplastic agent, is mainly limited by cardiotoxicity, although other tissues including liver are also affected. The effects of exercise to cope with DOX side-effects has already been studied in the heart and brain, demonstrating successful results. However, the benefits of this non pharmacological strategy have not been so extensively checked in the liver. We ...
Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory s...
Passos, E; Pereira, CD; Gonçalves, IO; Rocha-Rodrigues, S; Silva, N; Guimarães, JT; Neves, D; Ascensão, A; Magalhães, J; Martins, MJAims Pro-inflammatory mediators, glucocorticoids and transforming growth factor (TGF)-β are implicated in the pathogenesis of non-alcoholic steatohepatitis (NASH)-related insulin resistance. As physical activity is beneficial against NASH, we analyzed the voluntary physical activity (VPA) and endurance training (ET) (preventive and therapeutic strategies) effects on hepatic insulin, pro-inflammatory and glucoco...
Exercise mitigates diclofenac-induced liver mitochondrial dysfunction
Santos-Alves, E; Marques-Aleixo, I; Coxito, P; Balça, MM; Rizo-Roca, D; Rocha-Rodrigues, S; Martins, S; Torrella, JR; Oliveira, PJ; Moreno, AJBackground: Several strategies have been developed to counteract liver injury as a consequence of nonsteroid anti-inflammatory drugs toxicity. Here, we aimed to determine whether physical exercise results in liver mitochondrial protection against in vitro diclofenac toxicity. Material and methods: Male adult Sprague-Dawley rats were divided into sedentary, 12-week endurance training (ET) and voluntary activity ...