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Physiological, biochemical and functional changes induced by a simulated 30 min...

Ascensao, A; Azevedo, V; Ferreira, R; Oliveira, E; Marques, F; Magalhaes, J

Aim. Up to now, few studies regarding the impact of motocross heats on functional and physiological variables have been addressed so far. The aim of the present study was to analyze physiological and functional changes induced by a simulated off-road motocross heat. Methods. Fifteen motocross riders (28.3 +/- 7.9 yrs; 71.1 +/- 7.0 kg; 1.69.0 +/- 4.0 cm; 53.5 +/- 3.7 mL.kg(-1).min(-1); 14.9 +/- 3.3% fat) perform...


Strenuous exercise aggravates MDMA-induced skeletal muscle damage in mice

Duarte, JA; Leao, A; Magalhaes, J; Ascensao, A; Bastos, ML; Amado, FL; Vilarinho, L; Quelhas, D; Appell, HJ; Carvalho, F

The aim of this study was to investigate the influence of ecstasy (MDMA) administration on body temperature and soleus muscle histology in exercised and non-exercised mice. Charles-River mice were distributed into four groups: Control (C), exercise (EX), MDMA treated (M), and M + EX. The treated animals received an i.p. injection (10 mg/kg) of MDMA (saline for C and EX), and the exercise consisted of a 90 min l...


Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopa...

Ascensao, A; Magalhaes, J; Soares, JMC; Ferreira, R; Neuparth, MJ; Marques, F; Oliveira, PJ; Duarte, JA

The objective of this work was to test the hypothesis that endurance training may be protective against in vivo doxorubicin (DOX)-induced cardiomyopathy through mitochondria-mediated mechanisms. Forty adult (6-8 wk old) male Wistar rats were randomly divided into four groups (n=10/group): nontrained, nontrained + DOX treatment (20 mg/kg), trained (14 wk of endurance treadmill running, 60-90 min/day), and traine...


Effect of a high-altitude expedition to a Himalayan peak (Pumori, 7,161 m) on p...

Magalhaes, J; Ascensao, A; Marques, F; Soares, JMC; Ferreira, R; Neuparth, MJ; Duarte, JA

The effects of a high-altitude exposure were studied in six mountaineers who spent 3 weeks at an altitude range between 5,250 and 7,161 m after I week in an acclimatization trek (2,800-5,250 m). Blood drawn from the antecubital vein was collected at sea level I day before and I day after the expedition to analyse some haematological variables [haemoglobin (Hb), haematocrit (Htc) and red blood cell (RBC) count],...


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