3 documents found, page 1 of 1
Trypanosoma cruzi nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase-1) bi...
Mariotini-Moura, Christiane; Bastos, Matheus Silva e; Castro, Felipe Freitas de; Trindade, Mellina Lanna; Vasconcellos, Raphael de SouzaPrevious work has suggested that Trypanosoma cruzi diphosphohydrolase 1 (TcNTPDase-1) may be involved in the infection of mammalian cells and serve as a potential target for rational drug design. In this work, we produced recombinant TcNTPDase-1 and evaluated its nucleotidase activity, cellular localization and role in parasite adhesion to mammalian host cells. TcNTPDase-1 was able to utilize a broad range of t...
NTPDase-1 de Trypanosoma cruzi: imunolocalização e estudo de seu papel nas etap...
Trindade, Mellina LannaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior; Chagas disease, also known as American trypanosomiasis, is a tropical disease caused by the protozoan Trypanosoma cruzi that is found mainly in Latin America and currently affects roughly 10 million people worldwide. This disease is transmitted to humans and over 150 species of domestic and wild mammals through the feces of triatomas infected while fe...
Trypanosoma cruzi nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase-1) bi...
Moura, Christiane Mariotini; Bastos, Matheus Silva e; Castro, Felipe Freitas de; Trindade, Mellina Lanna; Vasconcellos, Raphael de SouzaPrevious work has suggested that Trypanosoma cruzi diphosphohydrolase 1 (TcNTPDase-1) may be involved in the infection of mammalian cells and serve as a potential target for rational drug design. In this work, we produced recombinant TcNTPDase-1 and evaluated its nucleotidase activity, cellular localiza- tion and role in parasite adhesion to mammalian host cells. TcNTPDase-1 was able to utilize a broad range of...