2 documents found, page 1 of 1
Grooved poly(lactide-co-trimethylene carbonate) substrates in tenogenic media m...
Ribeiro, S.; Pugliese, E.; Korntner, S. H.; Fernandes, E. M.; Gomes, Manuela E.; Reis, R. L.; O'Riordan, A.; Kearns, S.; Kelly, J. L.; Biggs, M.Tissue engineering strategies for tendon repair and regeneration rely heavily on the use of tendon derived cells. However, these cells frequently undergo phenotypic drift in vitro, which compromises their therapeutic potential. In order to maintain the phenotype of tendon derived cells in vitro, microenvironmental cues (biophysical, biochemical and/or biological in origin) have been used to better imitate the c...
Assessing the combined effect of surface topography and substrate rigidity in h...
Ribeiro, S.; Pugliese, E.; Korntner, S. H.; Fernandes, Emanuel Mouta; Gomes, Manuela E.; Reis, R. L.; O’Riordan, A.; Bayon, Y.; Zeugolis, D. I.The combined effect of surface topography and substrate rigidity in stem cell cultures is still under-investigated, especially when biodegradable polymers are used. Herein, we assessed human bone marrow stem cell response on aliphatic polyester substrates as a function of anisotropic grooved topography and rigidity (7 and 12 kPa). Planar tissue culture plastic (TCP, 3 GPa) and aliphatic polyester substrates wer...