2 documents found, page 1 of 1
Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers...
Sumaria, Nital; Fiala, Gina; Inácio, Daniel; Curado Avelar, Marta Maria; Cachucho, Ana; Pinheiro, Rúben; Wiesheu, Robert; Kimura, ShunsukeThe contribution of γδ T cells to immune responses is associated with rapid secretion of interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T cells that express CD8αβ heterodimers and expand in preclinical models of infection and cancer. Optimal CD8αβ+ γδ T cell development is directed by low T cell receptor signaling and through provision of interleukin (IL)-4 and IL-7. Th...
Triggering the TCR developmental checkpoint activates a therapeutically targeta...
Trinquand, Amelie; dos Santos, Nuno R.; Quang, Christine Tran; Rocchetti, Francesca; Zaniboni, Benedetta; Belhocine, Mohamed; de Jesus, Cindy Da CostaCancer onset and progression involves the accumulation of multiple oncogenic hits, which are thought to dominate or bypass the physiologic regulatory mechanisms in tissue development and homeostasis. We demonstrate in T-cell acute lymphoblastic leukemia (T-ALL) that, irrespective of the complex oncogenic abnormalities underlying tumor progression, experimentally induced, persistent T-cell receptor (TCR) signali...