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A circuit from hippocampal CA2 to lateral septum disinhibits social aggression

Leroy, Felix; Park, Jung; Asok, Arun; Brann, David H; Meira, Torcato Duarte Novo; Boyle, Lara M; Buss, Eric W; Kandel, Eric R; Siegelbaum, Steven A

Although the hippocampus is known to be important for declarative memory, it is less clear how hippocampal output regulates motivated behaviours, such as social aggression. Here we report that pyramidal neurons in the CA2 region of the hippocampus, which are important for social memory, promote social aggression in mice. This action depends on output from CA2 to the lateral septum, which is selectively enhanced...

Date: 2018 | Origin: RepositóriUM - Universidade do Minho

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