14 documents found, page 1 of 2
Course of serological tests in treated subjects with chronic Trypanosoma cruzi ...
Sguassero, Yanina; Roberts, Karen N.; Harvey, Guillermina B.; Comandé, Daniel; Cuesta, Cristina B.; Aguiar, Camila; Castro, Ana M. de; Danesi, EmmaríaObjective To determine the course of serological tests in subjects with chronic Trypanosoma cruzi infection treated with anti-trypanosomal drugs. Methods A systematic review and meta-analysis was conducted using individual participant data. Survival analysis and the Cox proportional hazards regression model with random effects to adjust for covariates were applied. The protocol was registered in the PROSPERO da...
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated fr...
Silva, Jaquelline Carla Valamiel de Oliveira e; Assis, Girley Francisco Machado de; Oliveira, Maykon Tavares de; Paiva, Nívia Carolina Nogueira deTrypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinh...
Trypanosoma cruzi Discret Typing Units (TcII and TcVI) in samples of patients f...
Oliveira, Maykon Tavares de; Assis, Girley Francisco Machado de; Silva, Jaquelline Carla Valamiel de Oliveira e; Machado, Evandro Marques de MenezesBackground: Trypanosoma cruzi is classified into six discrete taxonomic units (DTUs). For this classification, different biological markers and classification criteria have been used. The objective was to identify the genetic profile of T. cruzi samples isolated from patients of two municipalities of Jequitinhonha Valley, MG, Brazil. Methods: Molecular characterization was performed using two different criteria...
Evaluation of the Chagas disease control program in Açucena Municipality, Rio D...
Santos, Adriana dos; Letro, Rejane Balmant; Bem, Vitor Antônio Lemos do; Azeredo, Bernardino Vaz de Mello; Coelho, George Luiz Lins MachadoAçucena Municipality, Rio Doce Valley, State of Minas Gerais, Brazil temporarily (2001-2005) interrupted epidemiological surveillance for Chagas disease. The objective of this work was to evaluate the Chagas Disease Control Program (CDCP) in Açucena and to offer suggestions for improving local epidemiological surveillance. Methods: This study was conducted in three phases: I) a serological investigation of scho...
Molecular and biological characterization of Trypanosoma cruzi strains isolated...
Silva, Jaquelline Carla Valamiel de Oliveira e; Assis, Girley Francisco Machado de; Oliveira, Maykon Tavares de; Valadares, Helder Magno SilvaThe biological diversity of Trypanosoma cruzi strains plays an important role in the clinical and epidemiological features of Chagas disease. Methods: Eight T. cruzi strains isolated from children living in a Chagas disease vector-controlled area of Jequitinhonha Valley, State of Minas Gerais, Brazil, were genetically and biologically characterized. Results: The characterizations demonstrated that all of the st...
A serological, parasitological and clinical evaluation of untreated Chagas dise...
Assis, Girley Francisco Machado de; Diniz, Glaucia Alessio; Montoya, Roberto Araújo; Dias, João Carlos Pinto; Coura, José RodriguesThe etiological treatment of Chagas disease is recommended for all patients with acute or recent chronic infection, but controversies remain regarding the benefit of chemotherapy and interpretations of the parasitological cure after etiological treatment. This study compares the laboratory and clinical evaluations of Chagas disease patients who were diagnosed 13 years earlier. Fifty-eight Chagas disease patient...
Clinical and laboratory status of patients with chronic Chagas disease living i...
Lana, Marta de; Lopes, Leonardo de Araújo; Martins, Helen Rodrigues; Bahia, Maria Terezinha; Assis, Girley Francisco Machado deTwenty-eight Chagas disease patients (CD), 22 with the indeterminate clinical form (IND) and six with the cardiac or digestive form (CARD/DIG), were treated with benznidazole and underwent clinical and laboratorial analysis before (IND and CARD/DIG) and nine years after [patients after treatment (CDt), patients with the indeterminate clinical form at treatment onset (INDt) and with the cardiac or digestive form...
Innovations in diagnosis and post-therapeutic monitoring of Chagas disease : si...
Alessio, Glaucia Diniz; Côrtes, Denise Fonseca; Assis, Girley Francisco Machado de; Sales Júnior, Policarpo Ademar; Ferro, Eloisa Amália VieiraThis study developed a remarkable methodological innovation (FC-ATE) which enables simultaneous detection of antibodies specific to the three evolutive forms of Trypanosoma cruzi: live amastigote (AMA), live trypomastigote (TRYPO), and fixed epimastigote (EPI) using a differential fluorescence staining as low (AMA), intermediate (TRYPO), and high (EPI). An outstanding performance (100%) was observed in the disc...
Entomological surveillance of Chagas disease in Berilo municipality, Jequitinho...
Assis, Girley Francisco Machado de; Azeredo, Bernardino Vaz de Mello; Gorla, David; Diotaiuti, Liléia Gonçalves; Lana, Marta deO objetivo deste estudo foi avaliar o Programa de Controle de doença de Chagas instalado desde 1982 no município de Berilo, Vale do Jequitinhonha, MG, Brasil, baseado na avaliação de 5.242 unidades domiciliares e 7.807 anexos após oito anos de implantação da vigilância epidemiológica que ocorreu em 1997. Um total de 391 triatomíneos (280 Panstrongylus megistus e 111 Triatoma pseudomaculata) foram capturados, in...
In-house ELISA method to analyze anti-Trypanosoma cruzi IgG reactivity for diff...
Santos, Lilian da Silva; Torres, Rosália Morais; Assis, Girley Francisco Machado de; Bahia, Maria Terezinha; Martins, Helen RodriguesO objetivo foi desenvolver um método sorológico in-house de alta especificidade e sensibilidade para diagnosticar e monitorar a morbidade da doença de Chagas. Métodos: Para tal, a reatividade sorológica de IgG e subclasses foi testada em soros de pacientes chagásicos de Berilo, Vale do Jequitinhonha/MG/Brasil. A reatividade sorológica foi também avaliada em amostras de pacientes com outras doenças infecto-conta...