3 documents found, page 1 of 1
Leptin prevents lipopolysaccharide-induced depressive-like behaviors in mice: i...
Cordeiro, Rafaela Carneiro; Chaves Filho, Adriano José Maia; Medeiros, Camila Dantas; Queiroz, Ana Isabelle de Góis; Maes, Michael; Macedo, Danielle S.Depression is a chronic and recurrent disorder, associated with high morbidity and risk of suicide. Leptin was firstly described as an anti-obesity hormone, but several actions of leptin in CNS have been reported. In fact, leptin regulates dopaminergic neurotransmission in mesolimbic areas and has antidepressant-like properties in stress-based models. In the present study, we investigated, for the first time, p...
Preclinical evidences for an antimanic effect of carvedilol
Souza, Greicy Coelho de; Gomes, Julia Ariana de S.; Queiroz, Ana Isabelle de Góis; Araújo, Maíra Morais de; Cavalcante, Lígia MenezesOxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that CVD woul...
Angiotensin receptor blockers for bipolar disorder
Queiroz, Ana Isabelle de Góis; Medeiros, Camila Dantas; Ribeiro, Bruna Mara Machado; Lucena, David Freitas de; Macêdo, Danielle SilveiraStudies have suggested that the brain renin angiotensin system (RAS) regulates cerebral flow, autonomic and hormonal systems, stress, innate immune response and behavior, being implicated in several brain disorders such as major depression, Parkinson’s and Alzheimer’s disease. The angiotensin II receptor sub- type 1 (AT1R) is distributed in brain regions responsible for the control of stress response through pe...