4 documents found, page 1 of 1
CDH1 methylation in peritoneal washes as a prognostic factor for gastric cancer
Oliveira, Ana Carolina Favacho Miranda de; Modesto, Antonio André Conde; Moreira, Fabiano Cordeiro; Araújo, Taíssa Maíra ThomazGastric cancer is a major public health problem, considered the fifth most frequently diagnosed cancer worldwide. Peritoneal metastasis is the main causes of mortality related to gastric cancer. The hypermethylation of tumor suppressors genes is a promising factor for the development of predictive biomarkers. In gastric tumors, reduced expression of CDH1 suppressor gene contributes to tumor invasion and trigger...
Deregulated expression of SRC, LYN and CKB kinases by DNA methylation and its p...
Mello, Adriano Azevedo; Leal, Mariana Ferreira; Rey, Juan Antonio; Pinto, Giovanny Rebouças; Lamarão, Leticia Martins; Montenegro, Raquel CarvalhoKinases are downstream modulators and effectors of several cellular signaling cascades and play key roles in the development of neoplastic disease. In this study, we aimed to evaluate SRC, LYN and CKB protein and mRNA expression, as well as their promoter methylation, in gastric cancer. We found elevated expression of SRC and LYN kinase mRNA and protein but decreased levels of CKB kinase, alterations that may h...
Genetic screening analysis of patients with hereditary diffuse gastric cancer f...
Moreira-Nunes, Caroline Aquino; Barros, Mariceli Baia Leão; Borges, Bárbara do Nascimento; Montenegro, Raquel Carvalho; Lamarão, Leticia MartinsBackground: Hereditary diffuse gastric cancer (HDGC) is a hereditary autosomal inherited syndrome associated with CDH1 germline mutations. In Brazil, gastrointestinal tumors are among the most prevalent tumor types and constitute a serious public health problem, especially in the northern and northeastern regions. This study aimed to investigate germline mutations, methylation pattern and genomic rearrangements...
Occurrence of Helicobacter pylori and Epstein-Barr virus infection in endoscopi...
Souza, Carolina Rosal Teixeira de; Oliveira, Kátia Soares de; Ferraz, Jefferson José Sodré; Leal, Mariana Ferreira; Calcagno, Danielle QueirozBackground: Helicobacter pylori (HP) and Epstein-Barr virus (EBV) have been associated with cancer development. We evaluated the prevalence of HP, HP CagA+ and EBV infection in gastric cancer (GC) samples from adults and in gastric tissues from patients who underwent upper endoscopy (UE). Methods: Samples from UE and GC were collected to investigate the presence of HP infection and the HP virulence factor CagA ...