Funding Information: The authors would like to acknowledge financial support from Fundação para a Ciência e a Tecnologia, Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through projects PTDC/EQU–EQU/32473/2017, and PTDC/MEC–ONC/29327/2017. A.I.F. acknowledges her PhD grant (SFRH/BD/150696/2020) in the aim of the International Year of the Periodic Table – a Protocol established between...
Funding Information: The institutions are funded by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNO-VA4Health (UIDB/04462/2020 and UIDP/04462/2020), to MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020) and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). During the course of PhD, Cindy Mendes was funded by Lig...
Publisher Copyright: © The Author(s) 2025.; Correction to: Cancer Gene Therapyhttps://doi.org/10.1038/s41417-025-00906-8, published online 27 April 2025 The article 'Lactate-coated polyurea-siRNA dendriplex: a gene therapy directed and metabolism-based strategy to impair glioblastoma (GBM)', written by Filipa Martins, Renata Arada, Hélio Barros, Paulo Matos, José Ramalho, Valentín Ceña, Vasco D. B. Bonifácio, L...
Funding Information: The institutions are funded by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), to MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020) and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). The NMR data was acquired at CERMAX, ITQB-NOVA, Oeiras, P...
Predicting patient response to treatment and the onset of chemoresistance are still major challenges in oncology. Chemoresistance is deeply influenced by the complex cellular interactions occurring within the tumor microenvironment (TME), including metabolic crosstalk. We have previously shown that ex vivo tumor tissue cultures derived from ovarian carcinoma (OvC) resections retain the TME components for at lea...