5 documents found, page 1 of 1
Infection and Immunosuppression as Causes for Immune Dysfunction Presenting as ...
Atalaia Barbacena, Henrique; Quadros Flores, Maria Ana; Matias Lopes, Inês; Guiomar, Margarida; Howell-Monteiro, PatríciaN/A; N/A
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic ...
Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, NunoIn Alzheimer's disease (AD), amyloid β (Aβ)-triggered cleavage of TrkB-FL impairs brain-derived neurotrophic factor (BDNF) signaling, thereby compromising neuronal survival, differentiation, and synaptic transmission and plasticity. Using cerebrospinal fluid and postmortem human brain samples, we show that TrkB-FL cleavage occurs from the early stages of the disease and increases as a function of pathology seve...
Predictors of Long-COVID-19 and its Impact on Quality of Life: Longitudinal Ana...
Gaspar, Pedro; Dias, Mariana; Parreira, Inês; Gonçalves, Hélder Diogo; Parlato, Federica; Maione, Valeria; Atalaia Barbacena, HenriqueIntroduction: Long-COVID-19 impacts health-related quality of life (HR-QoL) but data is scarce. The aim of this study was to describe and prospectively assess the prevalence and risk factors for long-COVID-19 after hospital discharge, and to evaluate its impact on patient HR-QoL.Methods: Single-centre longitudinal study including all COVID-19 patients discharged between December 2020 and February 2021. Patients...
Controversies about the cardiovascular effects of OM3FA. Did inappropriate plac...
Vale, Fernando Martins do; Diógenes, Maria José; Atalaia Barbacena, HenriqueSeveral observational studies suggest that greasy fish may reduce cardiovascular risk, whose benefits have been attributed to the presence Omega-3 polyunsaturated fatty acids (OM3FA). However, there are some randomized controlled trials (RCTs) that have shown contradictory results concerning the cardiovascular benefits of OM3FA. Analyzing these RCTs we found that the use of olive oil in some RCTs could be respo...
Humoral immune response of SARS-CoV-2-infected patients with cancer: influencin...
Esperança Martins, Miguel; Gonçalves, Lisa; Soares De Pinho, Inês; Gomes, Andreia; Montesinos Serrano, Marta; Blankenhaus, BirteBackground: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with cancer show worse outcomes compared with patients without cancer. The humoral immune response (HIR) of patients with cancer against SARS-CoV-2 is not well characterized. To better understand it, we conducted a serological study of hospitalized patients with cancer infected with SARS-CoV-2. Materials and methods: This...