19 documents found, page 1 of 2
Application of curcuminoids in inflammatory, neurodegenerative and aging condit...
Lagoa, Ricardo; Rajan, Logesh; Violante, Cristiana; Babiaka, Smith B.; Marques da Silva, Dorinda; Kapoor, Bhupinder; Reis, Flávio; Atanasov, Atanas G.Curcumin, a natural compound found in turmeric, has shown promise in treating brain-related diseases and conditions associated with aging. Curcumin has shown multiple anti-inflammatory and brain-protective effects, but its clinical use is limited by challenges like poor absorption, specificity and delivery to the right tissues. A range of contemporary approaches at the intersection with bioengineering and syste...
Modified drug delivery systems for veterinary use: pharmaceutical development a...
Souto, Eliana B.; Barbosa, Catarina I.; Baldim, Iara; Campos, Joana R.; Fernandes, Ana R.; Mazzola, Priscila G.; Andreani, Tatiana; Dias, Isabel R.Scientific research in the field of veterinary pharmacology has provided new opportunities for the development of modified release dosage forms, with the aim to improve therapeutic efficacy and reduce animal stress. The formulation of classical drug molecules with advanced biomaterials has become a new approach to increasing drug bioavailability and improving the therapeutic outcome. The main reasons for the de...
Lycopene: total-scale literature landscape analysis of a valuable nutraceutical...
Yeung, Andy Wai Kan; Choudhary, Neeraj; Tewari, Devesh; El-Demerdash, Amr; Tomczyk, Michal; Das, Niranjan; Pirgozliev, Vasil; Lucarini, MassimoLycopene intake from tomatoes and other food sources has multiple potential health benefits. This report aimed to evaluate the current research literature on lycopene concerning human and animal health. The electronic Web of Science Core Collection database was searched with (lycopene*) AND (health* OR illness* OR disease* OR medic* OR pharma* OR drug* OR therap*). The resulted 3972 papers were analyzed with th...
Natural products in diabetes research: quantitative literature analysis
Yeung, Andy Wai Kan; Tzvetkov, Nikolay T.; Durazzo, Alessandra; Lucarini, Massimo; Souto, Eliana Maria Barbosa; Santini, Antonello; Gan, Ren-YouThe current study aimed to identify which natural products and which research directions are related to the major contributors to academic journals for diabetes therapy. Bibliometric data were extracted from the Web of Science online database using the search string TOPIC=(natural product* OR natural compound* OR natural molecule* OR phytochemical* OR secondary metabolite*) AND TS=(diabet*) and analysed by a bi...
Animal versus human research reporting guidelines impacts: literature analysis ...
Yeung, Andy Wai Kan; Wang, Dongdong; El-Demerdash, Amr; Horbanczuk, Olaf K.; Das, Niranjan; Pirgozliev, Vasil; Lucarini, Massimo; Durazzo, AlessandraThe present study evaluated for the first time citation-impacts of human research reporting guidelines in comparison to their animal version counterparts. Re-examined and extended also were previous findings indicating that a research reporting guideline would be cited more for its versions published in journals with higher Impact Factors, compared to its duplicate versions published in journals with lower Impa...
Big impact of nanoparticles: analysis of the most cited nanopharmaceuticals and...
Yeung, Andy Wai Kan; Souto, Eliana B.; Durazzo, Alessandra; Lucarini, Massimo; Novellino, Ettore; Tewari, Devesh; Wang, Dongdong; Atanasov, Atanas G.Nanopharmaceuticals and nanonutraceuticals research has been lately receiving a lot of scientific attention.We aimed to identify the top 100 most cited original articles of the scientific area, analyze their research themes, major contributors regarding authors, institutions, countries and journals. The bibliometric data was extracted from theWeb of Science electronic database. Data was further processed by a b...
(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant A...
Souto, Eliana B.; Zielińska, Aleksandra; Souto, Selma B; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Atanasov, Atanas G.In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized with Poloxamer® 188 in aqueous dispersion to modify the release profile of the loaded monoterpene derivative. We also evaluated the role of SLNs in lipid peroxidation and cytotoxicity in a spontaneously transformed aneuploid immortal keratinocyte cell line from a...
Perillaldehyde 1,2-epoxide Loaded SLN-Tailored mAb: Production, Physicochemical...
Souto, Eliana B.; Souto, Selma B.; Zielińska, Aleksandra; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Horbańczuk, Olaf K.We have developed a new cationic solid lipid nanoparticle (SLN) formulation, composed of Compritol ATO 888, poloxamer 188 and cetyltrimethylammonium bromide (CTAB), to load perillaldehyde 1,2-epoxide, and surface-tailored with a monoclonal antibody for site-specific targeting of human epithelial growth receptor 2 (HER2). Perillaldehyde 1,2-epoxide-loaded cationic SLN (cPa-SLN), with a mean particle size (z-Ave)...
(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant A...
Souto, Eliana B.; Zielinska, Aleksandra; Souto, Selma B.; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Silva, Amélia M.In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized with Poloxamer® 188 in aqueous dispersion to modify the release profile of the loaded monoterpene derivative. We also evaluated the role of SLNs in lipid peroxidation and cytotoxicity in a spontaneously transformed aneuploid immortal keratinocyte cell line from a...
Big impact of nanoparticles: analysis of the most cited nanopharmaceuticals and...
Yeung, Andy Wai Kan; Souto, Eliana B.; Durazzo, Alessandra; Lucarini, Massimo; Novellino, Ettore; Tewari, Devesh; Wang, Dongdong; Atanasov, Atanas G.Nanopharmaceuticals and nanonutraceuticals research has been lately receiving a lot of scientific attention. We aimed to identify the top 100 most cited original articles of the scientific area, analyze their research themes, major contributors regarding authors, institutions, countries and journals. The bibliometric data was extracted from the Web of Science electronic database. Data was further processed by a...