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Exercise-induced desaturation in subjects with non-cystic fibrosis bronchiectas...
Oliveira,Cristiane Helga Yamane de; José,Anderson; Camargo,Anderson Alves de; Feltrim,Maria Ignez Zanetti; Athanazio,Rodrigo Abensur; Rached,Samia ZahiABSTRACT Objective: To investigate the validity of field walking tests to identify exercise-induced hypoxemia and to compare cardiorespiratory responses and perceived effort between laboratory-based and field-based exercise tests in subjects with bronchiectasis. Methods: This was a cross-sectional study involving 72 non-oxygen-dependent participants (28 men; mean age = 48.3 ± 14.5 years; and mean FEV1 = 54.1 ± ...
Symptom variability over the course of the day in patients with stable COPD in ...
Cukier,Alberto; Godoy,Irma de; Costa,Claudia Henrique da; Rubin,Adalberto Sperb; Gregorio,Marcelo Gervilla; Albuquerque Neto,Aldo Agra deABSTRACT Objective: To analyze symptoms at different times of day in patients with COPD. Methods: This was a multicenter, cross-sectional observational study conducted at eight centers in Brazil. We evaluated morning, daytime, and nighttime symptoms in patients with stable COPD. Results: We included 593 patients under regular treatment, of whom 309 (52.1%) were male and 92 (15.5%) were active smokers. The mean ...
Maternal and Perinatal Outcomes in Pregnant Women with Cystic Fibrosis
Osmundo Junior,Gilmar de Souza; Athanazio,Rodrigo Abensur; Rached,Samia Zahi; Francisco,Rossana Pulcineli VieiraAbstract Objectives To assess the perinatal and maternal outcomes of pregnant women with cystic fibrosis (CF) and severe lung impairment. Methods This was a series of cases aiming to review the maternal and fetal outcomes in cases of singleton pregnant women with a diagnosis of CF. We have included all of the cases of singleton pregnancy in patients with CF who were followed-up at the obstetrics department of t...
Brazilian consensus on non-cystic fibrosis bronchiectasis
Pereira,Mônica Corso; Athanazio,Rodrigo Abensur; Dalcin,Paulo de Tarso Roth; Figueiredo,Mara Rúbia Fernandes de; Gomes,MauroABSTRACT Bronchiectasis is a condition that has been increasingly diagnosed by chest HRCT. In the literature, bronchiectasis is divided into bronchiectasis secondary to cystic fibrosis and bronchiectasis not associated with cystic fibrosis, which is termed non-cystic fibrosis bronchiectasis. Many causes can lead to the development of bronchiectasis, and patients usually have chronic airway symptoms, recurrent i...
2018 recommendations for the management of community acquired pneumonia
Corrêa,Ricardo de Amorim; Costa,Andre Nathan; Lundgren,Fernando; Michelin,Lessandra; Figueiredo,Mara Rúbia; Holanda,Marcelo; Gomes,MauroABSTRACT Community-acquired pneumonia (CAP) is the leading cause of death worldwide. Despite the vast diversity of respiratory microbiota, Streptococcus pneumoniae remains the most prevalent pathogen among etiologic agents. Despite the significant decrease in the mortality rates for lower respiratory tract infections in recent decades, CAP ranks third as a cause of death in Brazil. Since the latest Guidelines o...
The pulmonary microbiome: challenges of a new paradigm
Costa,André Nathan; Costa,Felipe Marques da; Campos,Silvia Vidal; Salles,Roberta Karla; Athanazio,Rodrigo AbensurABSTRACT The study of the human microbiome-and, more recently, that of the respiratory system-by means of sophisticated molecular biology techniques, has revealed the immense diversity of microbial colonization in humans, in human health, and in various diseases. Apparently, contrary to what has been believed, there can be nonpathogenic colonization of the lungs by microorganisms such as bacteria, fungi, and vi...
Brazilian guidelines for the diagnosis and treatment of cystic fibrosis
Athanazio,Rodrigo Abensur; Silva Filho,Luiz Vicente Ribeiro Ferreira da; Vergara,Alberto Andrade; Ribeiro,Antônio Fernando; Riedi,Carlos AntônioABSTRACT Cystic fibrosis (CF) is an autosomal recessive genetic disorder characterized by dysfunction of the CFTR gene. It is a multisystem disease that most often affects White individuals. In recent decades, various advances in the diagnosis and treatment of CF have drastically changed the scenario, resulting in a significant increase in survival and quality of life. In Brazil, the current neonatal screening ...
Recommendations for the pharmacological treatment of COPD: questions and answers
Fernandes,Frederico Leon Arrabal; Cukier,Alberto; Camelier,Aquiles Assunção; Fritscher,Carlos Cezar; Costa,Cláudia Henrique daABSTRACT The treatment of COPD has become increasingly effective. Measures that range from behavioral changes, reduction in exposure to risk factors, education about the disease and its course, rehabilitation, oxygen therapy, management of comorbidities, and surgical and pharmacological treatments to end-of-life care allow health professionals to provide a personalized and effective therapy. The pharmacological...
Comparison between objective measures of smoking and self-reported smoking stat...
Stelmach,Rafael; Fernandes,Frederico Leon Arrabal; Carvalho-Pinto,Regina Maria; Athanazio,Rodrigo Abensur; Rached,Samia Zahi; Prado,Gustavo FaibischewOBJECTIVE: Smoking prevalence is frequently estimated on the basis of self-reported smoking status. That can lead to an underestimation of smoking rates. The aim of this study was to evaluate the difference between self-reported smoking status and that determined through the use of objective measures of smoking at a pulmonary outpatient clinic. METHODS: This was a cross-sectional study involving 144 individuals...
Adalimumab-induced acute interstitial lung disease in a patient with rheumatoid...
Dias,Olivia Meira; Pereira,Daniel Antunes Silva; Baldi,Bruno Guedes; Costa,Andre Nathan; Athanazio,Rodrigo Abensur; Kairalla,Ronaldo AdibThe use of immunobiological agents for the treatment of autoimmune diseases is increasing in medical practice. Anti-TNF therapies have been increasingly used in refractory autoimmune diseases, especially rheumatoid arthritis, with promising results. However, the use of such therapies has been associated with an increased risk of developing other autoimmune diseases. In addition, the use of anti-TNF agents can c...