11 documents found, page 1 of 2
Synthesis, in silico Study and Antileishmanial Evaluation of New Selenides Deri...
Huang,Min-Fu N.; Luis,José A. S.; Silva,Alison P. da; Rocha,Juliana C.; Lima,Tatjana K. S.; Scotti,Marcus T.; Scotti,Luciana; Oliveira,Rafael F. deThis study describes a virtual screening performed for two series of selenides (28 compounds), derived from N-phenylacetamides chlorides and 7-chloro-quinoline, to determine their potential for leishmanicidal activity against Leishmania amazonensis and Leishmania donovani. Seven compounds were predicted as potential leishmanicides; therefore, they were synthesized from elemental selenium, as a precursor for the...
Synthesis, in silico Study and Antimicrobial Evaluation of New Diesters Derived...
Oliveira,Rafael F. de; Souza,Helivaldo D. S.; Alves,Francinara S.; Sousa,Abraão P. de; Lima,Priscila S. V. de; Huang,Min-Fu N.; Cordeiro,Laísa V.New diesters derived from phthaloylglycine (7a-7i) were synthesized and their structures characterized by infrared, 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. The compounds were evaluated in an in silico study, which demonstrated positive features indicating a possible drug candidate. The diesters showed antifungal activity ranging from moderate to strong against strains of Candida. Compounds 7a,...
New Diesters Derived from Piperine: in silico Study and Evaluation of Their Ant...
Trindade,Emmely O.; Souza,Helivaldo D. S.; Brandão,Maria Cláudia R.; Neto,Hermes D.; Lima,Edeltrudes O.; Lira,Bruno F.; Athayde-Filho,Petrônio F. dePiperine, previously extracted from black pepper (Piper nigrum L.), was used as a precursor for the synthesis of twelve new diester derivatives. The final products were obtained through the bimolecular nucleophilic substitution reaction (SN2) of the alkyl 2-chloroacetates and the salt of piperic acid, obtained from the basic hydrolysis of piperine. The compounds were synthesized with yields of 55-84% and charac...
Lignocellulosic Residues from the Brazilian Juice Processing Industry as Novel ...
Alves,José L. F.; Trindade,Emmely O. da; Silva,Jean C. G. da; Mumbach,Guilherme D.; Alves,Ricardo F.; Barbosa Filho,José M.This work aims to investigate the energy-related characteristics of apple bagasse, orange bagasse and cashew-apple bagasse to identify their potential as bioenergy feedstocks. For this, a detailed characterization was performed, including proximate analysis, ultimate analysis, atomic molar ratio, heating values, chemical composition, bulk density, bioenergy density, fuel-value-index (FVI), fossil fuel equivalen...
Synthesis, in silico Study and Antimicrobial Activity of New Piperine Derivativ...
Trindade,Emmely O.; Dutra,Thalisson F.; Brandão,Maria C. R.; Diniz Neto,Hermes; Lima,Edeltrudes O.; Lira,Bruno F.; Athayde-Filho,Petrônio F. deA series of fifteen new piperine-derived diesters was synthesized through the substitution reaction between the salt of piperic acid, obtained through piperine basic hydrolysis, with the δ-chloro-esters, obtained through the cleavage of tetrahydrofuran (THF) with acyl chlorides in the presence of ZnCl2. The final compounds were obtained with yields ranging from 50 to 84% and were characterized by infrared (IR) ...
Synthesis and Antifungal Activity Against Candida Strains of Mesoionic System D...
Peixoto,Isabelle N.; Souza,Helivaldo D. S.; Lira,Bruno F.; Silva,Daniele F.; Lima,Edeltrudes O.; Barbosa-Filho,José M.; Athayde-Filho,Petrônio F. deA series of ten new compounds have been synthetized in satisfactory yields (85-95%) through the treatment of isopropyl mesoionic 1,3-thiazolium-5-thiolate with 2-chloro-N-arylacetamides and characterized by elemental analysis, infrared (IR), 1H and 13C nuclear magnetic resonance (NMR) spectroscopies. The newly synthesized compounds were evaluated as new drug candidates in in silico study and for their antifunga...
Synthesis and testing of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazol...
Oliveira,Cledualdo S. de; Lira,Bruno F.; Barbosa-Filho,José M.; Lorenzo,Jorge G. F.; Menezes,Camilla P. de; Santos,Jessyca M. C. G. dosA series of 21 1,3,4-oxadiazoline derivatives was synthesized by cyclization of N-acylhydrazones with acetic anhydride and evaluated for their in vitro antifungal activity against six Candida strains: Candida albicans (ATCC 90028 and LM V-42), C. krusei (ATCC 6258 and LM 12 C) and C. tropicalis (ATCC 13803 and LM 14). The Candida strains were found to be sensitive to some of the compounds, which inhibited the g...
1,3-thiazolium-5-thiolates mesoionic compounds: semiempirical evaluation of the...
Lyra,Bruno F.; Morais,Soraya A. de; Rocha,Gerd B.; Miller,Joseph; Moura,Gustavo L. C.; Simas,Alfredo M.; Peppe,Clovis; Athayde-Filho,Petrônio F. deSemiempirical AM1-TDHF calculations of the static first hyperpolarizabilities, β(0), of 1,3-thiazolium-5-thiolate mesoionic derivatives were performed. Guided by these results, two new mesoionic compounds - 2-(4-nitrophenyl)-3-methyl-4-(methylphenyl)-1,3-thiazolium-5-thiolate and 2-(4-nitrophenyl)-3-methyl-4-(methoxyphenyl)-1,3-thiazolium-5-thiolate - were synthesized and characterized by analytical and spectro...
Plants with anticonvulsant properties: a review
Quintans Júnior,Lucindo J.; Almeida,Jackson R.G.S.; Lima,Julianeli T.; Nunes,Xirley P.; Siqueira,Jullyana S.; Oliveira,Leandra Eugênia Gomes deSeizures are resistant to treatment with currently available anticonvulsant drugs in about 1 out of 3 patients with epilepsy. Thus, there is a need for new, more effective anticonvulsant drugs for intractable epilepsy. However, nature is a rich source of biological and chemical diversity and a number of plants in the world have been used in traditional medicine remedies, i.e., anticonvulsant, anxiolytic, analge...
Natural products with antileprotic activity
Barbosa-Filho,José M.; Nascimento Júnior,Francisco A. do; Tomaz,Anna Cláudia de Andrade; Athayde-Filho,Petrônio F. de; Silva,Marcelo S. daLeprosy is a chronic infectious disease caused by Mycobacterium leprae bacillus. It was considered to be an incurable disease for ages. Nowadays leprosy is a vanishing disease although we can meet it principally in the tropical zone countries. Brazil has the second greatest number of leprosy cases around the world with almost 30,000 new cases diagnosed in 2005. The present work constitutes a literature review o...