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Typhoid fever infection – Antibiotic resistance and vaccination strategies

Masuet-Aumatell, Cristina; Atouguia, Jorge

Funding Information: The manuscript was funded by Emergent BioSolutions . The study sponsors had no role in the writing of the manuscript or the decision to submit the manuscript for publication. Publisher Copyright: © 2020 Elsevier Ltd; Typhoid fever is a bacterial infection caused by the Gram-negative bacterium Salmonella enterica subspecies enterica serovar Typhi (S. Typhi), prevalent in many low- and middle...


Clinical study on the melarsoprol-related encephalopathic syndrome

Seixas, Jorge; Atouguia, Jorge; Josenando, Teófilo; Vatunga, Gedeão; Bilenge, Constantin Miaka Mia; Lutumba, Pascal; Burri, Christian

Melarsoprol administration for the treatment of late-stage human African trypanosomiasis (HAT) is associated with the development of an unpredictable and badly characterized encephalopathic syndrome (ES), probably of immune origin, that kills approximately 50% of those affected. We investigated the characteristics and clinical risk factors for ES, as well as the association between the Human Leukocyte Antigen (...


Infection by intestinal parasites, stunting and anemia in school-aged children ...

Oliveira, Dinamene; Ferreira, Filipa Santana; Atouguia, Jorge; Fortes, Filomeno; Guerra, António; Centeno-Lima, Sónia

PMID:26371758 WOS:000361604400016; Introduction: Intestinal parasites are responsible for morbidity in children worldwide, especially in low income countries. In the present study we determine the prevalence of intestinal parasites and explore its association with anemia and stunting in school-aged children. Methods: A cross-sectional study was conducted from September to October 2010 enrolling 328 children att...


Direct detection by the xpert MTB/RIF assay and characterization of multi and p...

Rabna, Paulo; Ramos, Jorge; Ponce, Gema; Sanca, Lilica; Mané, Morto; Armada, Ana; Machado, Diana; Vieira, Fina; Gomes, Victor F.; Martins, Elisabete

PMID:26017968 WOS:000355185600088; Background This study aimed to evaluate the usefulness of the Xpert MTB/RIF assay for the rapid direct detection of M. tuberculosis complex (MTBC) strains and rifampicin resistance associated mutations in a resource-limited setting such as Guinea-Bissau and its implications in the management of tuberculosis (TB) and drug resistant tuberculosis, complementing the scarce informa...


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