2 documents found, page 1 of 1
An immunogenetic view of COVID-19
Aguiar,Vitor R. C.; Augusto,Danillo G.; Castelli,Erick C.; Hollenbach,Jill A.; Meyer,Diogo; Nunes,Kelly; Petzl-Erler,Maria LuizaAbstract Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogeneity of susceptibility and protection to the viral infection and disease progression. Here, we review the...
A genetic variant in microRNA-146a is associated with sporadic breast cancer in...
Brincas,Heloisa Magagnin; Augusto,Danillo G.; Mathias,Carolina; Cavalli,Iglenir João; Lima,Rubens Silveira de; Kuroda,Flávia; Urban,Cícero de AndradeAbstract MicroRNAs (miRNAs) play an essential role in gene expression and affect the development of tumours, including breast cancer (BC). Polymorphisms in miRNA genes can affect the interaction of miRNAs with their target messenger RNA by interfering, creating or disrupting target sites. The single nucleotide polymorphism (SNP) rs2910164, located in the seed region of miR146a, was shown to be associated with B...