4 documents found, page 1 of 1
What Do Microglia Really Do in Healthy Adult Brain?
Augusto-Oliveira, Marcus; Arrifano, Gabriela P.; Lopes-Araújo, Amanda; Santos-Sacramento, Leticia; Takeda, Priscila Y.; Anthony, Daniel C.Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. In inflammation, stroke, aging, or infection, microglia have been shown to contribute to brain pathology in both deleterious and beneficial ways, which have been studied extensively. However, less is known about their role in the healthy adult brain. Astrocyte...
Adult Hippocampal Neurogenesis in Different Taxonomic Groups: Possible Function...
Augusto-Oliveira, Marcus; Arrifano, Gabriela P F; Malva, João O.; Crespo-Lopez, Maria ElenaAdult neurogenesis occurs in many species, from fish to mammals, with an apparent reduction in the number of both neurogenic zones and new neurons inserted into established circuits with increasing brain complexity. Although the absolute number of new neurons is high in some species, the ratio of these cells to those already existing in the circuit is low. Continuous replacement/addition plays a role in spatial...
In the heart of the Amazon: noncommunicable diseases and apolipoprotein E4 geno...
Arrifano, Gabriela P. F.; Alvarez-Leite, Jacqueline I.; Souza-Monteiro, José Rogério; Augusto-Oliveira, Marcus; Paraense, Ricardo; Macchi, Barbarella M.The Amazon River basin is the largest tropical forest in the world. Most of the Amazon belongs to Brazil, a developing country that currently faces huge challenges related to the consolidation of its universal healthcare system. Noncommunicable diseases (NCDs) are the leading cause of death in Brazil, accounting for 74% of all deaths, and NCDs are probably underestimated in Amazonian population because of their...
Genetic susceptibility to neurodegeneration in Amazon: apolipoprotein E genotyp...
Arrifano, Gabriela P. F.; Martín-Doimeadios, Rosa C. R.; Jiménez-Moreno, María; Fernández-Trujillo, Sergio; Augusto-Oliveira, MarcusHuman exposure to mercury is a serious problem of public health in Amazon. As in other vulnerable populations throughout the world, Amazonian riverine populations are chronically exposed to this metal and some symptoms of mercury intoxication were already detected in these populations. However, studies on the genetic susceptibility to mercury toxicity in the Amazon are scarce, and they tested a limited number o...