3 documents found, page 1 of 1
Evaluation of Gold Complexes to Address Bacterial Resistance, Quorum Sensing, B...
Marques, Ana; Carabineiro, Sónia A. C.; Aureliano, Manuel; Faleiro, LeonorThe authors acknowledge Município de Loulé for the support provided during the study. The authors are also thankful for the imaging analysis using the equipment available at the Light Microscopy Unit of ABC-UAlg that was partially supported by National Portuguese funding PPBI-POCI-01-0145-FEDER-22122. S.A.C.C. acknowledges FCT for Scientific Employment Stimulus-Institutional Call (CEEC-INST/00102/2018) and LA/P...
Gold compounds inhibit the ca2+-atpase activity of brain pmca and human neurobl...
Berrocal, Maria; Cordoba-Granados, Juan J.; Carabineiro, Sónia A.C.; Gutierrez-Merino, Carlos; Aureliano, Manuel; Mata, Ana M.BFU2017-85723-P PID2020-115512GB-I00 MCIN/AEI/10.13039/501100011033; Plasma membrane calcium ATPases (PMCA) are key proteins in the maintenance of calcium (Ca2+) homeostasis. Dysregulation of PMCA function is associated with several human pathologies, including neurodegenerative diseases, and, therefore, these proteins are potential drug targets to counteract those diseases. Gold compounds, namely of Au(I), are...
The ca2+-atpase inhibition potential of gold(I, iii) compounds
Fonseca, Custódia; Fraqueza, Gil; Carabineiro, Sónia A. C.; Aureliano, ManuelFundacao para a Ciencia e a Tecnologia (FCT) project UIDB/04326/2020 and Associate Laboratory for Green Chemistry-LAQV, financed by national funds from FCT/MCTES (UIDB/50006/2020).; The therapeutic applications of gold are well-known for many centuries. The most used gold compounds contain Au(I). Herein, we report, for the first time, the ability of four Au(I) and Au(III) complexes, namely dichloro (2-pyridinec...