84 documents found, page 1 of 9
Repurposing therapeutic drugs complexed to Vanadium in Cancer
De Sousa-Coelho, Ana Luísa; Fraqueza, Gil; Aureliano, M.Repurposing drugs by uncovering new indications for approved drugs accelerates the process of establishing new treatments and reduces the high costs of drug discovery and development. Metal complexes with clinically approved drugs allow further opportunities in cancer therapy—many vanadium compounds have previously shown antitumor effects, which makes vanadium a suitable metal to complex with therapeutic drugs,...
Evaluation of gold complexes to address bacterial resistance, quorum sensing, b...
Marques, Ana; Carabineiro, Sónia A. C.; Aureliano, M.; Faleiro, LThe worldwide increase in antibiotic resistance poses a significant challenge, and researchers are diligently seeking new drugs to combat infections and prevent bacterial pathogens from developing resistance. Gold (I and III) complexes are suitable for this purpose. In this study, we tested four gold (I and III) complexes, (1) chlorotrimethylphosphine gold(I); (2) chlorotriphenylphosphine gold(I); (3) dichloro(...
The preyssler-type polyoxotungstate exhibits anti-quorum sensing, antibiofilm, ...
Faleiro, Maria Leonor; Marques, Ana; Martins, João; Jordão, Luísa; Nogueira, Isabel; Gumerova, Nadiia I.; Rompel, Annette; Aureliano, M.The increase in bacterial resistance to antibiotics has led researchers to find new compounds or find combinations between different compounds with potential antibacterial action and with the ability to prevent the development of antibiotic resistance. Polyoxotungstates (POTs) are inorganic clusters that may fulfill that need, either individually or in combination with antibiotics. Herein, we report the ability...
Biological activity of gold compounds against viruses and parasitosis: a system...
Fonseca, Custódia; Aureliano, M.In this contribution, we provide an overview of gold compound applications against viruses or parasites during recent years. The special properties of gold have been the subject of intense investigation in recent years, which has led to the development of its chemistry with the synthesis of new compounds and the study of its applicability in various areas such as catalysis, materials, nanotechnology and medicin...
Vanadium and Melanoma: A systematic review
Amante, Cristina; De Sousa-Coelho, Ana Luísa; Aureliano, M.The application of metals in biological systems has been a rapidly growing branch of science. Vanadium has been investigated and reported as an anticancer agent. Melanoma is the most aggressive type of skin cancer, the incidence of which has been increasing annually worldwide. It is of paramount importance to identify novel pharmacological agents for melanoma treatment. Herein, a systematic review of publicatio...
Rationalizing the decavanadate(V) and oxidovanadium(IV) binding to G-Actin and ...
Giuseppe, Sciortino; Aureliano, M.; Eugenio, GarribbaThe experimental data collected over the past 15 years on the interaction of decavanadate(V) (V10O286-; V10), a polyoxometalate (POM) with promising anticancer and antibacterial action, with G-actin, were rationalized by using several computational approaches (docking, density functional theory (DFT), and molecular dynamics (MD)). Moreover, a comparison with the isostructural and more stable decaniobate(V) (Nb1...
Screening polyoxometalates as aquaporin inhibitors for cancer therapeutics
Pimpao, C.; Coxixo, A. S.; Aureliano, M.; Rompel, A.; Soveral, G.Aquaporins (AQPs) are transmembrane protein channels that facilitate the diffusion of water and glycerol across cell membranes, crucial for water and energy homeostasis. These proteins were found overexpressed in different cancer cells and tissues, being involved in cell proliferation and migration, tumor formation, and angiogenesis, suggesting their great potential as novel drug targets for cancer treatment. I...
Ecotoxicological assessment of the anticancer drug cisplatin in the polychaete ...
Fonseca, T. G. [UNESP]; Morais, M. B.; Rocha, T.; Abessa, D. M.S. [UNESP]; Aureliano, M.; Bebianno, M. J.Made available in DSpace on 2018-12-11T17:06:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Anticancer drugs are designed to inhibit tumor cell proliferation by interacting with DNA and altering cellular growth factors. When released into the waterbodies of municipal and hospital effluents these pharmaceutical compounds may ...
The P-type ATPase inhibiting potential of polyoxotungstates.
Gumerova, Nadiia; Krivosudský, Lukáš; Fraqueza, Gil; Breibeck, Joscha; Al-Sayed, Emir; Tanuhadi, Elias; Bijelic, Aleksandar; Fuentes, JuanPolyoxometalates (POMs) are transition metal complexes that exhibit a broad diversity of structures and properties rendering them promising for biological purposes. POMs are able to inhibit a series of biologically important enzymes, including phosphatases, and thus are able to affect many biochemical processes. In the present study, we analyzed and compared the inhibitory effects of nine different polyoxotungs...
The antibacterial activity of polyoxometalates: structures, antibiotic effects ...
Aureliano, M.; Bijelic, Aleksandar; Rompel, AnnettePolyoxometalates (POMs) are, mostly anionic, metal oxide compounds that span a wide range of tunable physical and chemical features rendering them very interesting for biological purposes, an continuously emerging but little explored field. Due to their biological and biochemical effects, including antitumor, -viral and -bacterial properties, POMs and POM-based systems are considered as promising future metallo...