32 documents found, page 1 of 4
Special issue “medical value of metal complexes and plant-derived compounds: bi...
Ścibior, Agnieszka; Aureliano, Manuel; Llopis, JuanThis Special Issue (SI), titled “Medical Value of Metal Complexes and Plant-Derived Compounds: Biological Evaluation, Health Effects, Challenges, and Future Opportunities”, aims to include reports updating our knowledge about the effects of exposure to prevalent heavy metals in the environment, which adversely affect animal and human health. It also focuses on certain natural plant bioactive compounds with mult...
Editorial on the themed issue in honor of Carlos Gutiérrez Merino: forty years ...
Samhan-Arias, Alejandro K.; López-Sánchez, Carmen; Aureliano, ManuelProf. Carlos Gutiérrez-Merino has led over 30 research projects funded by national and international agencies and, under his guidance, numerous researchers have developed their doctoral theses, contributing to the growth of biomedical research in Extremadura.
Mixed-valence pentadecavanadate with Ca2+-ATPase inhibition potential and anti-...
Brito, Bianca R.; Camilo, Heloísa de S.; Cruz, Anderson F. da; Ribeiro, Ronny R.; Sá, Eduardo L. de; Oliveira, Carolina Camargo de; Fraqueza, GilPolyoxovanadates are a subclass of polyoxometalates (POMs) known to interact with proteins and to present anticancer, antimicrobial, and antiviral activities. Herein, we aimed to pursue the study of the breast anticancer activity of a mixed-valence polyoxovanadate, [Cl@VV 7V IV 8O36] 6− (V15) against MCF-7 and MDA-MB-231 cancer cell lines and to analyze its Ca2+-ATPase inhibition potential. 51V NMR and UV-Vis/N...
Selected Papers from the XXI SPB National Congress of Biochemistry 2021
Aureliano, Manuel; Cancela, Leonor; Costa, Ana R.; Antunes, Célia M.No abstract
Unveiling the agonistic properties of Preyssler-type Polyoxotungstates on purin...
Poejo, Joana; Gumerova, Nadiia I.; Rompel, Annette; Mata, Ana M.; Aureliano, Manuel; Gutierrez-Merino, CarlosThe Preyssler-type polyoxotungstate ({P5W30}) belongs to the family of polyanionic metal-oxides formed by group V and VI metal ions, such as V, Mo and W, commonly known as polyoxometalates (POMs). POMs have demonstrated inhibitory effect on a significant number of ATP-binding proteins in vitro. Purinergic P2 receptors, widely expressed in eukaryotic cells, contain extracellularly oriented ATP-binding sites and ...
Emerging topics in metal complexes: Pharmacological activity
Ścibior, Agnieszka; Aureliano, Manuel; Llopis, JuanThis Special Issue (SI), ”Emerging Topics in Metal Complexes: Pharmacological Activity”, includes reports updating our knowledge on metals with multidirectional biological properties and metal-containing compounds/complexes for their potential therapeutic applications, with a focus on strategies improving their pharmacological features. The current SI also refers to the biofortification process, which, in the n...
Polyoxometalates impact as anticancer agents
Carvalho, Fátima; Aureliano, ManuelPolyoxometalates (POMs) are oxoanions of transition metal ions, such as V, Mo, W, Nb, and Pd, forming a variety of structures with a wide range of applications. Herein, we analyzed recent studies on the effects of polyoxometalates as anticancer agents, particularly their effects on the cell cycle. To this end, a literature search was carried out between March and June 2022, using the keywords “polyoxometalates”...
Biological consequences of Vanadium effects on formation of reactive oxygen spe...
Aureliano, Manuel; De Sousa-Coelho, Ana Luísa; Dolan, Connor C.; Roess, Deborah A.; Crans, Debbie C.Lipid peroxidation (LPO), a process that affects human health, can be induced by exposure to vanadium salts and compounds. LPO is often exacerbated by oxidation stress, with some forms of vanadium providing protective effects. The LPO reaction involves the oxidation of the alkene bonds, primarily in polyunsaturated fatty acids, in a chain reaction to form radical and reactive oxygen species (ROS). LPO reactions...
Metals and metal complexes in diseases with a focus on COVID-19: facts and opin...
Ścibior, Agnieszka; Aureliano, Manuel; Holder, Alvin A.; Llopis, JuanIn the present Special Issue on “Metals and Metal Complexes in Diseases with a Focus on COVID-19: Facts and Opinions”, an attempt has been made to include reports updating our knowledge of elements considered to be potential candidates for therapeutic applications and certain metal-containing species, which are extensively being examined towards their potential biomedical use due to their specific physicochemic...
The biological applications of metals and metal complexes
Aureliano, Manuel; Gumerova, Nadiia I.; Rompel, AnnetteOver the course of biological evolution, approximately 25 to 30 elements have been recognized as essential for the proper functioning of biological systems since the emergence of life [...]