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Antileishmanial activity evaluation of poly(thymolformaldehyde)—A biobased mate...
Parolin, Giovana A.; Passero, Luiz Felipe D. [UNESP]; Lago, João Henrique G.; Péres, Laura OliveiraMade available in DSpace on 2022-04-28T19:43:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); A new biobased compound was prepared from commercially available monoterpene thymol, obtained from the...
Phenylnaphthalic anhydrides from water hyacinth (Pontederia crassipes Mart.)
Costa, Mayra F. [UNESP]; Luiz, Mayara M. [UNESP]; de Souza, Leonardo C. [UNESP]; Tempone, Andre G.; Lago, João Henrique G.Made available in DSpace on 2022-04-28T19:44:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Nineteen compounds were isolated from the aerial parts and roots of Pontederia crassipes Mart. [≡ Eich...
Ursolic acid potentializes conventional therapy in experimental leishmaniasis
Jesus, Jéssica Adriana; Da Silva, Thays Nicolli Fragoso; Yamamoto, Eduardo Seiji; Lago, João Henrique G.; Laurenti, Márcia DalastraMade available in DSpace on 2021-06-25T11:02:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-01; Ursolic acid (UA) is a triterpene with a broad array of pharmacological activities. In leishmaniasis, UA killed different species of parasites, and it was active in the experimental model of cutaneous and visceral leishmaniasis. Thus, the objective of this work was to study the therapeutic efficacy of t...
Biseugenol exhibited anti-Inflammatory and anti-asthmatic effects in an asthma ...
Lago, João Henrique G.
Improving the drug-likeness of inspiring natural products - evaluation of the a...
Morais, Thiago R.; Conserva, Geanne A. Alves; Varela, Marina T.; Costa-Silva, Thais A.; Thevenard, Fernanda; Ponci, Vitor; Fortuna, AnaNeolignan licarin A (1) was isolated from leaves of Nectandra oppositifolia (Lauraceae) and displayed activity against trypomastigote forms of the etiologic agent of American trypanosomiasis, Trypanosoma cruzi. Aiming for the establishment of SAR, five different compounds (1a - 1e) were prepared and tested against T. cruzi. The 2-allyl derivative of licarin A (1d) exhibited higher activity against trypomastigot...
Tolnaftate inhibits ergosterol production and impacts cell viability of Leishma...
Yamamoto, Eduardo Seiji; de Jesus, Jéssica Adriana; Bezerra-Souza, Adriana; Brito, Juliana R.; Lago, João Henrique G.; Laurenti, Márcia DalastraMade available in DSpace on 2020-12-12T02:14:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Leishmaniasis is an infectious disease caused by protozoan parasites of the genus Leishmania. The treatment of all forms of leishmaniasis relies on first-line drug, pentav...
Variação dos teores de constituintes voláteis de Cymbopogon citratus (DC) Staf,...
Furlan, Marcos R.; Martins, Roberto Carlos C.; Rodrigues, Eliana; Scalco, Nayara; Negri, Giuseppina; Lago, João Henrique G.Made available in DSpace on 2019-09-11T20:58:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2010; O óleo essencial extraído de Cymbopogon citratus (DC) Staf, Poaceae, é rico em citral sendo amplamente empregado na indústria química e farmacêutica. Os objetivos desse estudo foram avaliar o conteúdo de citral entre populações de C. citratus coletados em duas regiões diferentes (Ibiúna e Pindamonhangaba, Est...
Therapeutic effect of ursolic acid in experimental visceral leishmaniasis
Jesus, Jéssica A.; Fragoso, Thais N.; Yamamoto, Eduardo S.; Laurenti, Márcia D.; Silva, Marcelo S.; Ferreira, Aurea F.; Lago, João Henrique G.Made available in DSpace on 2018-12-11T17:08:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-04-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Leishmaniasis is an important neglected tropical disease, affecting more than 12 million people worldwide. The available treatments are not well tolerated and present diverse side effects in patients, justifying the search for new therapeuti...
Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira bac...
Bruno de Sousa, Carolina; Gangadhar, Katkam N.; Morais, Thiago R.; Conserva, Geanne A.A.; Vizetto-Duarte, Catarina; Pereira, Hugo; Laurenti, Márcia D.Made available in DSpace on 2018-12-11T17:09:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); The development of novel drugs for the treatment of leishmaniases continues to be crucial to overcome the severe impacts of these diseases on human and animal health. Seve...
In vitro trypanocidal evaluation of pinane derivatives from essential oils of r...
Sartorelli, Patricia; Santana, Jefferson S.; Guadagnin, Rafael C.; Lago, João Henrique G.; Pinto, Érika G.; Tempone, André G.; Stefani, Hélio A.Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pi...