3 documents found, page 1 of 1
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in...
de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, FrancescaSirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanisms involved remain unclear. Here, we provide mechanistic insight into the interplay between sirtuin 2 and α-synucl...
Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein...
Tenreiro, Sandra; Rosado Santos, Rita; Gerhardt, Ellen; Favretto, Filippo; Magalhães, Filipa; Popova, Blagovesta; Becker, Stefan; Zweckstetter, MarkusSynucleins belong to a family of intrinsically unstructured proteins that includes alpha-synuclein (aSyn), beta-synuclein (bSyn) and gamma-synuclein (gSyn). aSyn is the most studied member of the synuclein family due to its central role in genetic and sporadic forms of Parkinson's disease and other neurodegenerative disorders known as synucleionopathies. In contrast, bSyn and gSyn have been less studied, but re...
Systematic comparison of the effects of Alpha-synuclein mutations on its oligom...
Lázaro, Diana F.; Rodrigues, Eva F.; Langohr, Ramona; Shahpasandzadeh, Hedieh; Ribeiro, Thales; Guerreiro, Patrícia; Gerhardt, EllenAggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Furthermore, mutations in the gene encoding for ASYN are associated with familial and sporadic forms of PD, suggesting this protein plays a central role in the disease. However, the precise contribution of ASYN to neuronal dysfunction and death is u...