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Host determinants of infectiousness in smear-positive patients with pulmonary t...

Acuña-Villaorduña, Carlos; Ayakaka, Irene; Schmidt-Castellani, Luiz Guilherme; Mumbowa, Francis; Marques-Rodrigues, Patricia; Gaeddert, Mary

Background Epidemiologic data suggests that only a minority of tuberculosis (TB) patients are infectious. Cough aerosol sampling is a novel quantitative method to measure TB infectiousness. Methods We analyzed data from three studies conducted in Uganda and Brazil over a 13-year period. We included sputum acid fast bacilli (AFB) and culture positive pulmonary TB patients and used a cough aerosol sampling system...


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