8 documents found, page 1 of 1
Flavonoid Derivatives Targeting BCR-ABL Kinase: Semisynthesis, Molecular Dynami...
Ribeiro, Rayssa; Eloy, Mariana A.; Francisco, Carla S.; Javarini, Clara L.; Ayusso, Gabriela M. [UNESP]; Fonseca, Victor Da Rocha; Romão, WandersonMade available in DSpace on 2022-04-28T19:48:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Background: Natural products have been universally approached in the research of novel trends useful to detail the essential paths of the life sciences and as a stra...
Design, synthesis and antibacterial activity of chalcones against MSSA and MRSA...
Garcia, Mayara A.R. [UNESP]; Theodoro, Reinaldo S. [UNESP]; Sardi, Janaina C.O.; Santos, Mariana B. [UNESP]; Ayusso, Gabriela M. [UNESP]Made available in DSpace on 2022-04-29T08:32:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01; Staphylococcus aureus is the one of the most successful modern pathogens. The same bacterium that lives as a skin and mucosal commensal can be transmitted in health-care and community-settings and causes severe infections. Thus, there is a great challenge for a discovery of novel anti-Staphylococcus aur...
Curcumin-cinnamaldehyde hybrids as antiproliferative agents against women’s can...
Anselmo, Daiane B. [UNESP]; Polaquini, Carlos R. [UNESP]; Marques, Beatriz C. [UNESP]; Ayusso, Gabriela M. [UNESP]; Assis, Letícia R. [UNESP]Made available in DSpace on 2022-05-01T08:44:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Curcumin and cinnamaldehyde are natural products whose antineoplastic activity has been well explored in biological evaluations. However, their poor chemical stability under physiological conditions has been an obstacle to their use as therapeutic agents. Herein, we designed and synthesized two series o...
Investigating the Modes of Action of the Antimicrobial Chalcones BC1 and T9A
Morao, Luana G. [UNESP]; Lorenzoni, Andre S. G.; Chakraborty, Parichita; Ayusso, Gabriela M. [UNESP]; Cavalca, Lucia B.; Santos, Mariana B. [UNESP]Made available in DSpace on 2021-06-25T12:23:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-01; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Xanthomonas citri subsp. citri (X. citri) is an important phytopathogen and causes Asiatic Citrus Canker (ACC). To...
Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associ...
Polaquini, Carlos R. [UNESP]; Marques, Beatriz C. [UNESP]; Ayusso, Gabriela M. [UNESP]; Morão, Luana G. [UNESP]; Sardi, Janaína C.O.Made available in DSpace on 2021-06-25T10:52:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Curcumin (CUR) is a symmetrical dicarbonyl compound with antibacterial activity. On the other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic application. Monocarbonyl analogs of curcumin (MACs) have bee...
Antifungal activity of 2′-hydroxychalcone loaded in nanoemulsion against Paraco...
Medina-Alarcón, Kaila P [UNESP]; Singulani, Junya De L. [UNESP]; Dutra, Luiz A.; Pitangui, Nayla De S. [UNESP]; Pereira-Da-Silva, Marcelo A.Made available in DSpace on 2020-12-12T01:58:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Aim: This study aimed to evaluate the activity of 2′-hydroxychalcone-loaded in nanoemulsion (NLS + 2′chalc), the cytotoxic effect and toxicity against Paracoccidioides brasiliensis and Paracoccidioides lutzii using a zebrafish model. Materia...
A simplified curcumin targets the membrane of Bacillus subtilis
Morao, Luana G. [UNESP]; Polaquini, Carlos R. [UNESP]; Kopacz, Malgorzata; Torrezan, Guilherme S. [UNESP]; Ayusso, Gabriela M. [UNESP]Made available in DSpace on 2019-10-04T12:37:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-04-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Netherlands Organization for Scientific research; INCT Citros; Curcumin is the main constituent of turmeric, a seasoning popularized around the world with Indian cuisine. Among the benefits attributed to curcumin are anti-inflammatory, antim...
Prepubertal chrysin exposure upregulates either AR in male ventral prostate or ...
Ribeiro, Naiara C.S.; Campos, Mônica S. [UNESP]; Santos, Mariana B. [UNESP]; Ayusso, Gabriela M. [UNESP]; Vilamaior, Patrícia S.L. [UNESP]Made available in DSpace on 2018-12-11T17:16:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Chrysin is a plant-derived polyphenol that has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and by stimulating testicular steroidogenesis. The effects of chrysin on the prostate are unknown...