3 documents found, page 1 of 1
Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs a...
Redondo-Gómez, C; Parreira, P; Martins, MCL; Azevedo, HSSelf-assembled monolayers (SAMs) represent highly ordered molecular materials with versatile biochemical features and multidisciplinary applications. Research on SAMs has made much progress since the early begginings of Au substrates and alkanethiols, and numerous examples of peptide-displaying SAMs can be found in the literature. Peptides, presenting increasing structural complexity, stimuli-responsiveness, an...
Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular t...
Silva, J; Azevedo, HSHyaluronan (HA) is an extracellular matrix (ECM)-based polymer with unique physicochemical properties including biocompatibility, biodegradability, viscoelasticity, and high-water retention. However, its solubility in water drastically reduces its half-life in vivo. Through judicious chemical modifications, its structure is easily crosslinked and can conjugate with numerous therapeutic molecules, extending thei...
Phage Display Identified Peptide with Selectivity for Human Osteoarthritic Chon...
Martins, IM; Canadas, RF; Pereira, H; Azeredo, J; Reis, RL; Oliveira, JM; Azevedo, HSOsteoarthritis (OA) is one of the most common joint disorders in western populations, affecting millions of people worldwide and with a rising incidence as life expectancy continues to increase. Current therapies for OA management fail to halt the progressive degradation of articular cartilage, urging the need for more effective therapies to improve function and enhance quality of life. Through phage display te...