10 documents found, page 1 of 1
Bone turnover markers in sheep and goat: a review of the scientific literature
Camassa, José A.; Diogo, Camila C.; Sousa, Cristina P.; Azevedo, Jorge T.; Viegas, Carlos A.; Reis, R. L.; Dourado, N.; Dias, Isabel R.Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also dur...
Evaluation of bone turnover markers and serum minerals variations for predictin...
Sousa, Cristina P.; Lopez-Peña, Mónica; Guzon, Fernando M.; Abreu, Humberto V. de; Luís, Maurino R.; Viegas, Carlos A.; Camassa, José A.Bone turnover markers (BTMs) have been considered as an auxiliary method of following the fracture healing process and for early prediction of impaired bone healing. A better understanding of the potential of BTMs in this application could allow for earlier interventions and improved patient care. The aim of this study with a large animal experimental model was to assess the variation of bone formation markers ...
Tartrate-resistant acid phosphate as biomarker of bone turnover over the lifesp...
Camassa, José A.; Diogo, Camila C.; Bordelo, João P. A.; Bonelli, Marília de A.; Viegas, Carlos A.; Azevedo, Jorge T.; Dourado, Nuno; Dias, Isabel R.Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as early indicators of prognosis. However, there is a wide range of variability in bone turnover markers due to several factors, such as different ages and metabolic stages, thus it is important to have as much ...
Serum total and bone alkaline phosphatase levels and their correlation with ser...
Sousa, Cristina P.; Azevedo, Jorge T.; Silva, Amélia M.; Viegas, Carlos A.; Reis, R. L.; Gomes, Manuela E.; Dias, Isabel R.This study aimed to assess serum total alkaline phosphatase (ALP) and its bone isoform (BALP) levels during the ageing and in different physiologic states of sheep, in order to expand the knowledge about the variation of these biomarkers over the sheep lifespan. Ninety female sheep were divided into nine groups of various ages and physiological states (dry, lactation and pregnancy). Serum ALP, BALP and mineral ...
Enxertos e substitutos ósseos em cirurgia ortopédica reconstrutiva nos animais ...
Dias, Isabel R.; Sousa, Cristina Maria Peixoto de; Carvalho, Pedro Miguel Pires de; Lempeck, Marthin Raboch; Viegas, Carlos A.; Azevedo, Jorge T.We present here an overview of the scientific literature concerning the clinical application of autografts and allografts of the skeletal tissues and of the natural and synthetic bone graft substitutes available in small animal orthopedic surgery for resolution of congenital, traumatic and tumoral etiology situations or for reconstructive artroplastic surgeries. This article focuses the terminology, definitions...
Tissue-engineered constructs based on SPCL scaffolds cultured with goat marrow ...
Rodrigues, Marcia T.; Gomes, Manuela E.; Azevedo, Jorge T.; Guzon, Fernando M.; Reis, Rui L.; Dias, Isabel; Viegas, Carlos
Tissue engineered constructs based on SPCL scaffolds cultured with goat marrow ...
Rodrigues, Márcia T.; Gomes, Manuela E.; Viegas, Carlos A.; Azevedo, Jorge T.; Dias, Isabel R.; Guzon, Fernando M.; Reis, R. L.This study aims to assess the in vivo performance of cell–scaffold constructs composed of goat marrow stromal cells (GBMCs) and SPCL (a blend of starch with polycaprolactone) fibre mesh scaffolds at different stages of development, using an autologous model. GBMCs from iliac crests were seeded onto SPCL scaffolds and in vitro cultured for 1 and 7 days in osteogenic medium. After 1 and 7 days, the constructs wer...
Assessment of bone formation markers under controlled environmental conditions ...
Dias, Isabel R.; Viegas, Carlos A.; Azevedo, Jorge T.; Costa, E. M.; Lourenço, P.; Rodrigues, A.; Cabrita, A. S.Eighteen healthy skeletally mature (3 years old) ewes, with an average weight of 45 kg, of the Portuguese Churra da Terra Quente breed were used to evaluate the normal values of total and bone-specific isoform of alkaline phosphatase serum activities (ALP and BALP, respectively) and serum osteocalcin (OC) and their correlation with the serum minerals – calcium (Ca), phosphorus (P), magnesium (Mg) and ionized ca...
Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engin...
Oliveira, Joaquim M.; Rodrigues, Marcia T.; Silva, Simone S.; Malafaya, Patricia B.; Gomes, Manuela E.; Azevedo, Jorge T.; Mano, Joao F.; Reis, Rui L.
Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engin...
Oliveira, Joaquim M.; Rodrigues, Márcia T.; Silva, Simone Santos; Malafaya, P. B.; Gomes, Manuela E.; Viegas, Carlos A.; Azevedo, Jorge T.Recent studies suggest that bone marrow stromal cells are a potential source of osteoblasts and chondrocytes and can be used to regenerate damaged tissues using a tissue-engineering (TE) approach. However, these strategies require the use of an appropriate scaffold architecture that can support the formation de novo of either bone and cartilage tissue, or both, as in the case of osteochondral defects. The later...