36 documents found, page 1 of 4

Relationship between handedness and the incidence of spinal changes in the fron...

Sport practice and plantar pressure in children aged 10–18 years: evaluation us...

Antisense oligomers for controlling Candida albicans infections

International Patent; The present disclosure relates to the use of antisense oligomers in the treatment or therapy of Candida albicans infections. The present disclosure further describes the use of antisense oligomers in antisense therapy to inhibit the morphological transition of Candida albicans from yeast to filamentous form.; info:eu-repo/semantics/publishedVersion

Application of 2OMethylRNA antisense oligomer to control Candida albicans EFG1 ...

Antisense oligomers and their analogues have been successfully utilized to silence gene expression for the treatment of many human diseases; however the control of yeast´s virulence determinants has never been exploited before. In this sense, this work is based on the key hypothesis that if a pathogens genetic sequence is a determinant of virulence, it will be possible to synthesize a nucleic acid mimic based o...

2´OMethylRNA EFG1 antisense oligomer to control Candida albicans filamentation

Antisense oligomers (ASO) and their analogues have been successfully utilized to silence gene expression for the treatment of many human diseases, however the control of yeast´s virulence determinants have never been exploited before. In this sense, this work is based on the key hypothesis that if a pathogens genetic sequence is a determinant of virulence, it will be possible to synthesize a nucleic acid mimic ...

Antisense oligomers based approaches for controlling Candida albicans filamenta...

14th ASM Conference on Candida and Candidiasis; Introduction: The increase of multidrug resistance of Candida pathogenic species to the traditional antifungal agents and the scarcity of new classes of antifungal drugs led to the increased of the number of infections caused by Candida albicans . One of the most relevant virulence factors attributed to C. albicans is their ability to switch from yeast to filament...

Application of antisense oligomers based approaches to control candidiasis

Book of Abstracts of CEB Annual Meeting 2017; [Excerpt] Candidiasis is the primary fungal disease, with a mortality rate of about 40% and costs associated with hospitalized patients that range from €5700 to €85000 per episode. This important clinical, social and economic problem is due to the recognized phenomenon of Candida species multi-antifungal resistance, associated with the indiscriminate use of traditio...

Caracterização do comportamento dinâmico da barragem do Alto Ceira ii através d...

Na presente comunicação é apresentado o estudo de caracterização dinâmica da barragem do Alto Ceira II recorrendo a métodos experimentais e numéricos. Foi efetuada a caraterização deste comportamento para as situações de albufeira vazia e cheia através da realização de ensaios de vibração forçada e da medição de ruído ambiente. A interpretação dos resultados das campanhas de ensaio e a estimação das característ...

Melhoramentos recentes no projeto e instalação de células de fluência em barrag...

A presente comunicação descreve as características gerais das instalações experimentais in situ para a determinação da deformabilidade do betão de barragens, habitualmente designadas por células de fluência, e os melhoramentos realizados nos últimos anos no seu projeto e instalação. As células de fluência são provetes de betão embebidos no corpo das barragens para a execução de ensaios de determinação do módulo...

Experimental investigation on the composition, mechanical strength and self-cle...

The self-cleaning ability of photocatalytic cement-based materials has the potential to preserve the esthetic appearance of building facades over time thus reducing cleaning costs. In the present work , the joint effect of several factors on the mechanical strength and self-cleaning ability of photocatalytic mortars was studied. For this purpose, four different mortar mixes containing two binder/sand ratios (1:...