57 documents found, page 1 of 6
The effect of premature termination codon mutations on CFTR mRNA abundance in h...
Clarke, LA; Awatade, NT; Felício, VM; Silva, IA; Calucho, M; Pereira, L; Azevedo, P; Cavaco, J; Barreto, C; Bertuzzo, C; Gartner, S; Beekman, JA major challenge in cystic fibrosis (CF) research is applying mutation-specific therapy to individual patients with diverse and rare CF transmembrane conductance regulator (CFTR) genotypes. Read-through agents are currently the most promising approach for Class I mutations that introduce premature termination codons (PTCs) into CFTR mRNA. However, variations in degradation of PTC containing transcripts by nons...
Non-invasive hemodynamic evaluation by Doppler echocardiography
Gaspar, A; Azevedo, P; Roncon-Albuquerque, RThe approach for treating a hemodynamically unstable patient remains a diagnostic and therapeutic challenge. Stabilization of the patient should be rapid and effective, but there is not much room for error. This narrow window of intervention makes it necessary to use rapid and accurate hemodynamic evaluation methods. Echocardiography is the method of choice for the bedside evaluation of patients in circulatory ...
Spontaneous coronary artery dissection: A single-center case series and literat...
Abreu, G; Galvão Braga, C; Costa, J; Azevedo, P; Marques, JBACKGROUND: Spontaneous coronary artery dissection (SCAD) is an unusual cause of acute coronary syndrome (ACS). Better recognition and diagnosis has raised awareness of this condition. However, the pathophysiology of SCAD and its prognosis are still little understood. We aimed to investigate the characteristics and prognosis of patients with SCAD, and subsequently performed a review of literature. METHODS: Sing...
Assessment of asthma control using CARAT in patients with and without Allergic ...
Domingos, M; Amaral, R; Fonseca, JA; Azevedo, P; Correia-de-Sousa, JBACKGROUND: Asthma and Allergic Rhinitis (AR) are two chronic inflammatory diseases that are often concomitant. The Control of Allergic Rhinitis and Asthma Test (CARAT) was developed to evaluate the control of these diseases from the patients' perspective. Its performance in asthma patients without AR has not been previously studied. AIM: To test the hypothesis that CARAT can be used to assess asthma control in...
Atypical presentation of an intracardiac mass
Abreu, G; Azevedo, P; Bettencourt, N; Vieira, C; Arantes, C; Quina, C; Vilaça, A; Marques, J
Early discharge in selected patients after an acute coronary syndrome – can it ...
Abreu, G; Azevedo, P; Arantes, C; Quina-Rodrigues, C; Fonseca, S; Martins, J; Vieira, C; Salgado, A; Marques, J
Será o que parece?
Abreu, G; Rocha, S; Bettencourt, N; Quina-Rodrigues, C; Arantes, C; Martins, J; Fonseca, S; Vieira, C; Barbosa, L; Azevedo, P; Marques, J
Prevalence of cancer and its impact on prognosis of acute coronary syndrome pop...
Abreu, G; Azevedo, P; Arantes, C; Quina-Rodrigues, C; Fonseca, S; Martins, J; Vieira, C; Álvares-Pereira, M; Marques, J
Prevalence and outcomes of ST-segment elevation myocardial infarction patients ...
Abreu, G; Costa, J; Quina-Rodrigues, C; Arantes, C; Fonseca, S; Martins, J; Galvão-Braga, C; Vieira, C; Azevedo, P; Marques, J
An unusual trigger causing Takotsubo Syndrome
Abreu, G; Rocha, S; Bettencourt, N; Azevedo, P; Vieira, C; Rodrigues, C; Arantes, C; Braga, C; Martins, J; Marques, J