7 documents found, page 1 of 1
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxici...
Ganassin, Rayane; Da Silva, Victor Carlos Mello; Araujo, Victor Hugo Sousa; Tavares, Giulia Rosa; Da Silva, Patrícia Bento; Cáceres-Vélez, Paolin RocioMade available in DSpace on 2022-05-01T13:41:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01; Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN...
Liposomal paclitaxel induces apoptosis, cell death, inhibition of migration cap...
Faria, Raquel Santos; Lima, Luiza Ianny de; Bonadio, Raphael Severino; Longo, João Paulo Figueiró; Roque, Marjorie Coimbra; Matos Neto, João Nunes deThe main goal of this study is to evaluate the efficacy of the paclitaxel (PTX) drug formulated with a liposomal nanosystem (L-PTX) in a peritoneal carcinomatosis derived from ovarian cancer. In vitro cell viability studies with the human ovarian cancer line A2780 showed a 50% decrease in the inhibitory concentration for L-PTX compared to free PTX. A2780 cells treated with the L-PTX formulation demonstrated a r...
New prospects in neutering male animals using magnetic nanoparticle hyperthermia
Jivago, José Luiz P. R.; Brito, Juliana Lis Mendes; Capistrano, Gustavo; Araújo, Marcus Vinícius; Verde, Ediron Lima; Bakuzis, Andris FigueiroaControlling populations of free-roaming dogs and cats poses a huge challenge worldwide. Non-surgical neutering strategies for male animals have been long pursued, but the implementation of the procedures developed has remained limited to date. As submitting the testes to high temperatures impairs spermatogenesis, the present study investigated localized application of magnetic nanoparticle hyperthermia (MNH) to...
The influence of NLC composition on curcumin loading under a physicochemical pe...
Sousa Araujo, Victor Hugo; Silva, Patricia Bento da; Szlachetka, Isis Oliveira; Silva, Sebastiao William da; Fonseca-Santos, BrunoMade available in DSpace on 2020-12-12T00:07:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-05; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); The use of (nanostructured lipid carries) NLC to disperse curcumin in aqueous media is widely found in literature. However, few studies systematically analyze the influence of the lipid matrix composition and the presence of curcumin o...
Topical photodynamic therapy with chloroaluminum phthalocyanine liposomes is as...
Azevedo, Ricardo Bentes
Culture of human dental pulp cells at variable times post-tooth extraction
Benício, Daniela Ferreira Araújo; Pereira, Luciana Oliveira; Silva, Izabel Cristina Rodrigues da; Azevedo, Ricardo Bentes; Bezerra, Ana Cristina BarretoThe aim of this study was to investigate the viability of human dental pulp cells from extracted teeth kept at standard room temperature and atmospheric pressure for different periods of time. Twenty-one healthy permanent teeth were used. They were divided into five groups according to the expected time from extraction to processing. One group was tested immediately after extraction; the other groups were each ...
Characterization and Biological Activities of Ocellatin Peptides from the Skin ...
Marani, Mariela Mirta; Dourado, Flávio Santos; Quelemes, Patrick Veras; Araujo, Alyne Rodrigues de; Perfeito, Márcia Luana Gomes; Barbosa, Eder AlvesEight new peptides were isolated from the skin secretion of the frog Leptodactylus pustulatus and their amino acid sequences determined by de novo sequencing and by cDNA cloning. Structural similarities between them and other antimicrobial peptides from the skin secretion of Leptodactylus genus frogs were found. Ocellatins-PT1 to -PT5 (25 amino acid residues) are amidated at the C-terminus, while ocellatins-PT6...