13 documents found, page 1 of 2
Oral delivery of fish oil in oil-in-water nanoemulsion : development, colloidal...
Santos, Débora S.; Morais, José Athayde Vasconcelos; Vanderlei, Ísis A. C.; Santos, Alexandre S.; Azevedo, Ricardo Bentes de; Muehlmann, Luis AlexandreTo improve the oral absorption of fish oil and test its anti-inflammatory effect, a fish oil nanoemulsion was developed using cis-4,7,10,13,16,19-docosahexaenoic fatty acid as a biomarker for oral administration. The colloidal stability tests of the fish oil nanoemulsion showed an average size of 155.44 nm ± 6.46 (4 °C); 163.04 nm ± 9.97 (25 °C) and polydispersity index 0.22 ± 0.02 (4 °C), 0.21 ± 0.02 (25 °C), ...
DFT, molecular docking, and ADME/Tox screening investigations of market‑availab...
Araújo, Joabe Lima; Sousa, Lucas Aires de; Sousa, Alice O.; Bastos, Ruan Sousa; Santos, Gardênia Taveira; Lage, Mateus R.; Stoyanov, Stanislav R.A series of drugs was investigated to determine structural, electronic and pharmacological properties, as well as the molecular affinity for the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The drugs were submitted to density functional theory calculations to optimize structures and predict binding preferences. The optimized geometries were used in molecular docking simulations...
Labeling mesenchymal cells with DMSA-coated gold and iron oxide nanoparticles :...
Silva, Luisa H. A.; Silva, Jaqueline R. da; Ferreira, Guilherme A.; Silva, Renata C.; Lima, Emilia Celma de Oliveira; Azevedo, Ricardo Bentes deNanoparticles’ unique features have been highly explored in cellular therapies. However, nanoparticles can be cytotoxic. The cytotoxicity can be overcome by coating the nanoparticles with an appropriated surface modification. Nanoparticle coating influences biocompatibility between nanoparticles and cells and may affect some cell properties. Here, we evaluated the biocompatibility of gold and maghemite nanopart...
Evaluation of ovarian structures using computerized microtomography
Paulini, Fernanda; Chaves, Sacha Braun; Rôlo, José Luiz Jivago de Paula; Azevedo, Ricardo Bentes de; Lucci, Carolina MadeiraVisualization and clear understanding of the ovarian structures are important in determining the stage of oestrus, helping to diagnose several pathologies and supporting advances in reproductive technologies. In this research, computerized microtomography (microCT) was used to explore and characterize the ovarian structure of seven mammalian species. Ovaries of rats, female dog, queens, cows, mares, sows and a ...
Antitumor activity of photodynamic therapy performed with nanospheres containin...
Portilho, Flávia Arruda; Cavalcanti, Cláudio Eduardo de Oliveira; Miranda-Vilela, Ana Luisa; Estevanato, Luciana Landim CarneiroBackground: The increasing incidence of cancer and the search for more effective therapies with minimal collateral effects have prompted studies to find alternative new treatments. Among these, photodynamic therapy (PDT) has been proposed as a very promising new modality in cancer treatment with the lowest rates of side effects, revealing itself to be particularly successful when the photosensitizer is associat...
Antifungal activity of amphotericin B conjugated to nanosized magnetite in the ...
Saldanha, Camila Arruda; Garcia, Mônica Pereira; Iocca, Diego Cesar; Rebelo, Luciana Guilherme; Souza, Ana Camila Oliveira; Bocca, Anamélia LorenzettiThis study reports on in vitro and in vivo tests that sought to assess the antifungal activity of a newly developed magnetic carrier system comprising amphotericin B loaded onto the surface of pre-coated (with a double-layer of lauric acid) magnetite nanoparticles. The in vitro tests compared two drugs; i.e., this newly developed form and free amphotericin B. We found that this nanocomplex exhibited antifungal ...
Liposomal photosensitizers : potential platforms for anticancer photodynamic th...
Muehlmann, Luis Alexandre; Joanitti, Graziella Anselmo; Silva, Jaqueline Rodrigues da; Longo, João Paulo Figueiró; Azevedo, Ricardo Bentes dePhotodynamic therapy is a well-established and clinically approved treatment for several types of cancer. Antineoplastic photodynamic therapy is based on photosensitizers, i.e., drugs that absorb photons translating light energy into a chemical potential that damages tumor tissues. Despite the encouraging clinical results with the approved photosensitizers available today, the prolonged skin phototoxicity, poor...
A reduction in CD90 (THY-1) expression results in increased differentiation of ...
Moraes, Daniela Abreu de; Sibov, Tatiana T.; Pavon, Lorena F.; Alvim, Paula Queiroz; Bonadio, Raphael Severino; Silva, Jaqueline Rodrigues daBackground: Mesenchymal stromal cells (MSCs) are multipotent progenitor cells used in several cell therapies. MSCs are characterized by the expression of CD73, CD90, and CD105 cell markers, and the absence of CD34, CD45, CD11a, CD19, and HLA-DR cell markers. CD90 is a glycoprotein present in the MSC membranes and also in adult cells and cancer stem cells. The role of CD90 in MSCs remains unknown. Here, we sough...
HPLC-FLD method for itraconazole quantification in poly lactic-co-glycolic acid...
Py-Daniel, Karen Rapp; Pires Junior, Osmindo Rodrigues; Cordova, Carlos M. Infante; Fascineli, Maria Luiza; Tedesco, Antonio ClaudioItraconazol, um antifúngico de amplo espectro, possui muitos efeitos colaterais e o uso de nanossistemas para a entrega de fármacos tem sido proposto como um método para otimizar a farmacocinética da droga e reduzir os efeitos colaterais. Um procedimento de cromatografia líquida de alta performance (HPLC) utilizando detecção fluorimétrica foi desenvolvido para a determinação de itraconazol em nanopartículas do ...
PVM/MA-shelled selol nanocapsules promote cell cycle arrest in A549 lung adenoc...
Souza, Ludmilla Regina de; Muehlmann, Luis Alexandre; Santos, Mayara Simonelly Costa dos; Ganassin, Rayane; Simón-Vázquez, RosanaBackground: Selol is an oily mixture of selenitetriacylglycerides that was obtained as a semi-synthetic compound containing selenite. Selol is effective against cancerous cells and less toxic to normal cells compared with inorganic forms of selenite. However, Selol’s hydrophobicity hinders its administration in vivo. Therefore, the present study aimed to produce a formulation of Selol nanocapsules (SPN) and to ...