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Interplay between western diet and mammary cancer: data from a chemically-induc...

Silva, J; Azevedo, T; Aires, I; Peixoto, F; Neuparth, MJ; Faustino-Rocha, AI; Duarte, JA; Oliveira, PA

Background/Aim: This study aimed to investigate the influence of Western diet on mammary cancer in Wistar female rats, focusing on systemic responses and tumor development. Materials and Methods: Twenty-eight Wistar female rats were acclimatized and divided into four experimental groups (n=7 each): Western diet (WD), Western diet with N-methyl-N- nitrosourea (MNU) administration (WD+MNU), standard diet (CTR), a...


Effects of ladder-climbing exercise on mammary cancer: data from a chemically i...

Silva, J; Azevedo, T; Faustino-Rocha, AI; Oliveira, PA; Duarte, JA

Breast cancer is a major health concern for both humans and companion animals, particularly female dogs and cats. This study explores whether resistance training can influence the development of mammary cancer in female rats. The rats were divided into four groups, including those that exercised by climbing a ladder with increasing weight three times a week for 18 weeks. At the end of the study, tumor developme...


The impact of a Western diet and resistance training in a rat model of mammary ...

Silva, J; Azevedo, T; Faustino-Rocha AI; Duarte, JA; Oliveira, PA

This study aimed to investigate the impact of a Western diet and resistance training on cardiac remodeling in a rat model of chemically induced mammary cancer. Fifty-six female Wistar rats were randomly assigned to one of eight experimental groups, evaluating the impact of Western and standard diets, exercise and sedentarism, and the induction of mammary cancer. Mammary cancer was induced via the intraperitonea...


Studying and analyzing humane endpoints in the fructose-fed and streptozotocin-...

Silva-Reis, R; Faustino-Rocha, Ana I; Silva, J; Valada, A; Azevedo, T; Anjos, L; Gonçalves, L; Pinto, ML; Ferreira, R; Silva, AM; Cardoso, SM

This study assessed a humane endpoint scoring system to detect animal suffering in a rat model of type 2 diabetes. Sprague-Dawley male rats were divided into control and induced (fructose-fed and streptozotocin (STZ) administration) groups. Induced animals drank 10% fructose for 14 days, then received STZ (40 mg/kg) intraperitoneally. Weekly monitoring of body weight, water, and food consumption, 14 parameters ...


antolina chamaecyparissus L.: a brief overview of its medicinal properties

Azevedo, T; Faustino-Rocha, Ana I; Barros, L; Finimundy, TC; Matos, M; Oliveira, PA

Santolina chamaecyparissus, commonly known as cotton-lavender, is a plant with recog- nized medicinal properties that has been traditionally used in several conditions, including the relief of premenstrual syndrome, and the treatment of infections and digestive disorders. Its extracts have been found to have a range of therapeutic effects and can be used in modern medicine, due to their analgesic, anticancer, a...


Evaluating the impact of a western diet on biochemical parameters in an animal ...

Silva, A; Azevedo, T; Anjos, L; Faustino-Rocha, Ana I; Oliveira, Paula A; Duarte, JA

Breast cancer continues to affect millions of individuals worldwide. In this way, it is of paramount importance to understand the effects of dietary choices in this disease development. This work aimed to evaluate the influence of Western diet (WD) on biochemical parameters in an animal model of breast cancer. Twenty-eight female Wistar rats were divided into four groups (n=7): WD; WD+N-methyl- N-nitrosourea (M...


Effect of exercise training on hematological and biochemical parameters: data f...

Silva, J; Azevedo, T; Anjos, L; Moura, T; Faustino-Rocha, Ana I; Oliveira, PA; Duarte, JA

Breast cancer is the most common oncological disease among women. The lifestyle, including physical activity and diet may prevent it. This study assessed the impact of exercise training on hematological and biochemical parameters in a rat model of mammary cancer. Twenty-eight female rats were randomly divided into four groups (n=7): Sedentary (SED); SED+N-methyl-N-nitrosourea (MNU); Exercised (EX); and EX+MNU. ...


Effects of resistance training in the development of mammary tumors MNU-induced...

Silva, J; Azevedo, T; Valada, A; Anjos, L; Faustino-Rocha, Ana I; Oliveira, PA; Duarte, JA

Effects of resistance training in the development of mammary tumors MNU-induced in Wistar rats


Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemica...

Azevedo, T; Faustino-Rocha, Ana I; Silva, J; Valada, A; Anjos, L; Moura, T; Ferreira, R; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, F; Seixas, F

Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemically- induced mammary cancer


The effect of resistance training on hematological parameters: data from an ani...

Silva, J; Azevedo, T; Valada, A; Anjos, L; Silvestre-Ferreira, AC; Faustino-Rocha, Ana I; Queiroga, FL; Oliveira, PA; Duarte, JA

Breast cancer continues to be one of the main causes of death from cancer worldwide. Haematological analysis is not only useful to evaluate the animals’ health status, but also for the diagnosis and to study the progression of several diseases, including cancer. This study aimed to evaluate the effects of resistance training on haematological parameters in a rat model of mammary cancer. Twenty-eight female rats...


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