8 documents found, page 1 of 1
Structure-function relationship for the highly toxic crotoxin from Crotalus dur...
Mascarenhas, Yvonne P.; Stouten, Pieter F.W.; Beltran, José R. [UNESP]; Laure, Carlos J.; Vriend, GerritMade available in DSpace on 2022-04-28T19:53:53Z (GMT). No. of bitstreams: 0 Previous issue date: 1992-07-01; The three-dimensional structure of the highly toxic crotoxin from Crotalus durissus terrificus was modelled based on sequence analysis and the refined structure of calcium-free phospholipase of Crotalus atrox venom. Small-angle x-ray scattering experiments were performed on aqueous solutions of crotoxin...
Phase Characterization of Lead Zirconate Titanate Obtained from Organic Solutio...
Zaghete, Maria A.; Santos, Carlos O. Paiva; Varela, José A.; Longo, Elson; Mascarenhas, Yvonne P.Made available in DSpace on 2022-04-29T08:45:01Z (GMT). No. of bitstreams: 0 Previous issue date: 1992-01-01; Lead zirconate titanate (PZT) with several Zr/Ti ratios was prepared by the organic solution of citrates of the respective cations. The Rietveld method was applied to perform quantitative analysis of the coexisting phases. The ratio of tetragonal/rhombohedral phases increased with calcination temperatur...
Lactone derivatives produced by a Phaeoacremonium sp., an endophytic fungus fro...
Silva, Geraldo H.; Zeraik, Maria L.; Oliveira, Camila M. de; Teles, Helder L.; Trevisan, Henrique C.; Pfenning, Ludwig H.; Nicolli, Camila P.Three new isoaigialones, A, B, and C (1–3), along with aigialone (4), were isolated from the crude EtOAc extract of a Phaeoacremonium sp., an endophytic fungus obtained from the leaves of Senna spectabilis. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compounds 2 and 4 were active against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerosperm...
HPLC-DAD, ESI-MS/MS, and NMR of Lycopene Isolated From P. guajava L. and Its Bi...
Amorim, Adriany G. N.; Souza, Jessica M. T.; Santos, Raimunda C.; Gullón, Beatriz; Oliveira, Ana; Santos, Luiz F. A.; Virgino, Adamor L. E.Psidium guajava L. have been reported to be a rich source of antioxidant compounds. Its carotenoids have been highlighted by their high antioxidant capacity, which offers several benefits for human health. In this sense, lycopene isomers need to be identified. In this work, the comprehensive chemical characterization, by HPLC‐DAD, MS/MS, and NMR, of lycopene isolated from P. guajava L., antioxidant and antimicr...
Structure-function studies of BPP-BrachyNH 2 and synthetic analogues thereof wi...
Arcanjo, Daniel D.R.; Vasconcelos, Andreanne G.; Nascimento, Lucas A.; Mafud, Ana Carolina; Plácido, Alexandra; Alves, Michel M.M.The vasoactive proline-rich oligopeptide termed BPP-BrachyNH2 (H-WPPPKVSP-NH2) induces in vitro inhibitory activity of angiotensin I-converting enzyme (ACE) in rat blood serum. In the present study, the removal of N-terminal tryptophan or C-terminal proline from BPP-BrachyNH2 was investigated in order to predict which structural components are important or required for interaction with ACE. Furthermore, the tox...
Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids fr...
Rocha, Jefferson A.; Andrade, Ivanilza M.; Véras, Leiz M.C.; Quelemes, Patrick V.; Lima, David F.; Soares, Maria J.S.; Pinto, Pedro L.S.; Mayo, Simon J.Pilocarpus microphyllus Stapf ex Wardlew (Rutaceae), popularly known as jaborandi, is a plant native to the northern and northeastern macroregions of Brazil. Several alkaloids from this species have been isolated. There are few reports of antibacterial and anthelmintic activities for these compounds. In this work, we report the antibacterial and anthelmintic activity of five alkaloids found in P. microphyllus l...
Layer-by-layer films containing peptides of the Cry1Ab16 toxin from Bacillus th...
Plácido, Alexandra; Farias, Emanuel Airton de Oliveira; Marani, Mariela M.; Vasconcelos, Andreanne G.; Mafud, Ana C.; Mascarenhas, Yvonne P.Cry1Ab16 is a toxin of crystalline insecticidal proteins that has been widely used in genetically modified organisms (GMOs) to gain resistance to pests. For the first time, in this study, peptides derived fromthe immunogenic Cry1Ab16 toxin (from Bacillus thuringiensis) were immobilized as layer-by-layer (LbL) films. Given the concern about food and environmental safety, a peptide with immunogenic potential, PcL...
In Silico, In Vitro and In Vivo Toxicological Assessment of BPP-BrachyNH2, A Va...
Arcanjo, Daniel D. R.; Mafud, Ana Carolina; Vasconcelos, Andreanne G.; Silva-Filho, José Couras da; Amaral, Maurício P. M.; Brito, Lucas M.BPP-BrachyNH2 is a proline-rich oligopeptide (PRO) firstly identified in skin secretion of the frog Brachycephalus ephippium, which possess in vitro inhibitory activity of angiotensin-I converting enzyme (ACE) and endothelium-dependent vasorelaxant activity. Considering its potential application in the treatment of cardiovascular diseases, the present work assessed the toxicological profile of the BPP-BrachyNH2...