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The bright side of fibroblasts: molecular signature and regenerative cues in ma...

Gomes, RN; Manuel, F; Nascimento, DS

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by large amounts of extracellular matrix, which may lead to organ dysfunction and even death. Fibroblasts are classically associated to fibrosis and tissue repair, and seldom to regeneration. However, accumulating evidence supports a pro-regenerative role of fibroblasts in different organs. While some organs rely on fibrobla...


Triple Regimen with Rituximab, Plasmapheresis and Intravenous Immunoglobulin in...

Pessegueiro, P; Nolasco, F; Sampaio, S; Carvalho, F; Manuel, F; Barber, E; Viana, H; Sousa, J; Possante, M; Domingos, M; Reimão Pinto, J

Introduction: The clinical importance of humoral-mediated acute rejection has been progressively recognised. Early recognition and treatment with plasmapheresis and intravenous immunoglobulin have recently improved short term prognosis. Case report: In this report we describe the clinical features of three 2nd transplant patients developing severe acute humoral rejection during the first week post-transplant wh...


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