8 documents found, page 1 of 1
Update on treatments for Parkinson's disease motor fluctuations: an internation...
de Bie, Rob M. A.; Katzenschlager, Regina; Swinnen, Bart E. K. S.; Peball, Marina; Lim, Shen‐Yang; Mestre, Tiago; Perez Lloret, Santiago; Coelho, MiguelObjective: To update evidence-based medicine recommendations for treating motor fluctuations of Parkinson's disease (PD). Background: The International Parkinson and Movement Disorder Society (MDS) Evidence Based Medicine in Movement Disorders Committee recommendations for the treatments of PD were first published in 2002 and regularly updated. The current review uses a new methodology, including the Cochrane R...
Clinical utility of Opicapone in the management of Parkinson's Disease : a shor...
Azevedo Kauppila, Linda; Silva, Daniela; Ferreira, Joaquim JParkinson’s disease (PD) is a prevalent neurodegenerative disorder, and levodopa (L-dopa) remains the most efficacious drug treatment for PD and a gold-standard for symptom control. Nonetheless, a significant majority of PD patients develop motor fluctuations over their disease course, with a significant impact on quality-of-life, meaning control of such complications translates into a fundamental clinical need...
Validation of quantitative gait analysis systems for Parkinson’s disease for us...
Alberto, Sara; Cabral, Sílvia; Proença, João; Pona-Ferreira, Filipa; Leitão, Mariana; Bouça-Machado, Raquel; Azevedo Kauppila, Linda; Veloso, AntónioBackground: Gait impairments are among the most common and impactful symptoms of Parkinson’s disease (PD). Recent technological advances aim to quantify these impairments using low-cost wearable systems for use in either supervised clinical consultations or long-term unsupervised monitoring of gait in ecological environments. However, very few of these wearable systems have been validated comparatively to a cri...
Feasibility of a mobile-based system for unsupervised monitoring in Parkinson’s...
Bouça-Machado, Raquel; Pona-Ferreira, Filipa; Leitão, Mariana; Clemente, Ana; Vila-Viçosa, Diogo; Azevedo Kauppila, Linda; Costa, Rui M.Mobile health (mHealth) has emerged as a potential solution to providing valuable ecological information about the severity and burden of Parkinson's disease (PD) symptoms in real-life conditions. Objective: The objective of our study was to explore the feasibility and usability of an mHealth system for continuous and objective real-life measures of patients' health and functional mobility, in unsupervised sett...
Cardiovascular and cerebrovascular risk markers in Parkinson’s disease: results...
Alves, Mariana; Pita Lobo, Patrícia; Azevedo Kauppila, Linda; Rebordão, Leonor; Cruz, M. Manuela; Soares, Fátima; Cruz, João; Tornada, AnaBackground: The relationship between Parkinson's disease (PD) and cardiovascular and cerebrovascular disease is not yet well established. Recent data suggest an increased risk of myocardial infarction and stroke in PD patients. Therefore, we designed a study to assess surrogate markers of cardiovascular and cerebrovascular risk in PD. Methods: We conducted a case-control study comparing PD patients recruited fr...
Unsupervised walking activity assessment reveals COVID‐19 impact on Parkinson's...
Vila‐Viçosa, Diogo; Clemente, Ana; Pona‐Ferreira, Filipa; Leitão, Mariana; Bouça-Machado, Raquel; Azevedo Kauppila, Linda; Costa, Rui M.COVID-19 brought multiple societal challenges that became a catalyst for worsening health in people with Parkinson’s disease (PwPD) and brought disruption in their social activities. It is hypothesized that the COVID-19 confinement also impacted the functional mobility of PwPD. One of the building blocks of functional mobility is the ability to walk. It enables independence and participation in social activitie...
Anti-glutamic acid decarboxylase encephalitis presenting with choreo‐dystonic m...
Azevedo Kauppila, Linda; Coelho, Miguel; Franco, Ana Catarina; Teodoro, Tiago; Peralta, Ana Rita; Bentes, Carla; Falcão, Filipa; Albuquerque, LuísaGlutamic acid decarboxylase (GAD) antibodies (ab) have been associated with rare disorders, such as Stiff-person syndrome, limbic encephalitis, cerebellar ataxia, and temporal lobe epilepsy. Other systemic autoimmune disorders have been linked to antiGAD ab, among them, diabetes mellitus (DM).
Intravenous thrombolysis for acute ischemic stroke after recent myocardial infa...
Marto, João Pedro; Azevedo Kauppila, Linda; Jorge, Cláudia; Calado, Sofia; Viana-Baptista, Miguel; Melo, Teresa Pinho e; Fonseca, Ana CatarinaBackground and Purpose- The safety of IV r-tPA (intravenous tissue-type plasminogen activator) for acute ischemic stroke (AIS) treatment after recent myocardial infarction (MI) is still a matter of debate. We studied the safety of delivering IV r-tPA to AIS patients with a MI within the preceding 3 months. Methods- Retrospective review of consecutive AIS admitted to 2 tertiary university hospitals' and systemat...