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Frailty phenotype in heart failure: A condition that transcends age

Valdiviesso, Rui; Moreira, E; Martins, S; Azevedo L; Ataide, R; Lia Fernandes; Silva Cardoso, J; Borges, Nuno

Introduction and objectives: Studies on younger frail and pre-frail subjects suffering from heart failure (HF) are scarce, except for those focusing on the critically ill. This work aims to describe differences between younger (<65 years) and older (>= 65 years) pre-frail and frail HF outpatients regarding their nutritional, functional and clinical statuses.Methods: In this cross-sectional study, a sample of 99...


Frailty phenotype and associated nutritional factors in a sample of Portuguese ...

Valdiviesso, Rui; Azevedo L; Moreira, E; Ataíde, R; Martins, S; Lia Fernandes; Silva Cardoso, J; Borges, Nuno

Background and aim: Frailty phenotype (FP) is very common in heart failure (HF) and both syndromes worsen one another. The aim of this study is to first describe FP in a sample of Portuguese patients with HF, and to analyse its association with nutritional and clinical statuses, namely, muscle mass, obesity and functional class. Methods and results: In this cross-sectional study, a sample of 136 outpatients wit...


Pain as the fifth vital sign: a comparison between public and private healthcar...

Daniel Pozza; Azevedo L; Castro-Lopes J.M.

Background The assessment of pain as the fifth vital sign (P5VS) is of paramount importance since it leads to the management of undertreated pain, consequently reducing suffering, readmissions and emergency department visits after hospital discharge. Objective To evaluate the implementation of P5VS in public and private hospitals. Methods Data analysis on validated questionnaires was sent to all 171 Portuguese ...


Prevalence and determinants of motor stereotypies in autism spectrum disorder: ...

Melo, C; Azevedo L

Stereotypies are frequently reported in people with autism spectrum disorder (ASD) but remain one of the less explained phenomena. We aimed to describe, through a systematic review and a meta-analysis, the prevalence of motor stereotypies in ASD and study the factors that influence this prevalence. Our literature search included MEDLINE, Scopus, and PsycINFO databases. Quality and risk of bias were assessed. Th...


The Use of Glycomacropeptide in Patients with Phenylketonuria: A Systematic Rev...

Pena, MJ; Pinto, A; Daly, A; MacDonald, A; Azevedo L; rocha, jc; Borges, Nuno

In phenylketonuria (PKU), synthetic protein derived from L-amino acids (AAs) is essential in a low-phenylalanine (Phe) diet. Glycomacropeptide (GMP), an intact protein, is very low in Phe in its native form. It has been modified and adapted for PKU to provide an alternative protein source through supplementation with rate-limiting amino acids (GMP-AAs), although it still contains residual Phe. This review aims ...


Nociceptive behaviour upon modulation of mu-opioid receptors in the ventrobasal...

Daniel Pozza; Catarina Potes; Patricia Barroso; Azevedo L; Castro Lopes J.M.; Fani Neto

The role of mu-opioid receptors (MORs) in the inflammatory pain processing mechanisms within the ventrobasal complex of the thalamus (VB) is not well understood. This study investigated the effect of modulating MOR activity upon nociception, by stereotaxically injecting specific ligands in the VB. Nociceptive behaviour was evaluated in two established animal models of inflammatory pain, by using the formalin (a...


Imagem corporal de crianças/adolescentes obesos entre os 7 - 12 anos e seus pro...

Silva D; Rego C; Dias C; Azevedo L; Guerra A

Introdution: Body image and weight are a major source of concerne since early ages. The aim of thisstudy is to evaluate self-image among obese children and their parents.Patients and Methods: We evaluate 94 obese children/adolescents (M=48; F=46) and their parents,followed at the Nutrition Outpatient Pediatric Clinic. Study protocol included nutritional status andbody image (BMI: Frisancho) and their parents (B...


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