3 documents found, page 1 of 1
Liposomal Delivery of Saquinavir to Macrophages Overcomes Cathepsin Blockade by...
Pires, David; Mandal, Manoj; Pinho, Jacinta O.; Catalão, Maria João; Almeida, António J.; Azevedo-Pereira, J. M.; Gaspar, Maria Manuela; Anes, ElsaMycobacterium tuberculosis is able to establish a chronic colonization of lung macrophages in a controlled replication manner, giving rise to a so-called latent infection. Conversely, when intracellular bacteria undergo actively uncontrolled replication rates, they provide the switch for the active infection called tuberculosis to occur. Our group found that the pathogen is able to manipulate the activity of en...
Characterization of HIV-2 chimeric viruses unable to use CCR5 and CXCR4 corecep...
Santos-Costa, Q.; Mansinho, K.; Moniz-Pereiraa, J.; Azevedo-Pereira, J. M.We have previously shown the existence of primary human immunodeficiency virus type 2 isolates (MIC97 and MJC97) unable to use major coreceptors to entry into peripheral blood mononuclear cells, including CCR5 and CXCR4. We have now created a set of chime. - EU Program EVA/MRC [QLK2-CT-1999-00606]; UK Medical Research Council ; Fundacao da Ciencia e Tecnologia (FCT) [POCI/SAU-IMI/55726/2004]. - We are grateful ...
CHEMOKINE RECEPTORS AND ITS IMPORTANCE IN THE REPLICATION CYCLE OF HUMAN IMMUNO...
Azevedo-Pereira, J. M.; Santos-Costa, Q.Human immunodeficiency virus (HIV) infection of host cells begins with binding of viral envelope (Env) surface (SU) glycoprotein to specific receptors present at plasma cell membrane. One of these receptors is the CD4 molecule which can be found namely in