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Coreceptor Usage by HIV-1 and HIV-2 Primary Isolates: The Relevance of CCR8 Che...

Calado, M; Matoso, P; Santos-Costa, Q; Espirito-Santo, M; Machado, J; Rosado, L; Antunes, K; Mansinho, K; Lopes, MM; Maltez, F; Santos-Ferreira, MO

The human immunodeficiency virus replication cycle begins by sequential interactions between viral envelope glycoproteins with CD4 molecule and a member of the seven-transmembrane, G-protein-coupled, receptors' family (coreceptor). In this report we focused on the contribution of CCR8 as alternative coreceptor for HIV-1 and HIV-2 isolates. We found that this coreceptor was efficiently used not only by HIV-2 but...



Caracterização molecular do gene env de estirpes primárias VIH-2 CCR5/CXCR4 ind...

Santos-Costa, Q; Parreira, R; Moniz-Pereira, J; Azevedo-Pereira, JM




CCR8

Calado, Ana Marta; Espirito-Santo, Maria; Santos-Costa, Quirina; Machado, João; Antunes Francisco; Maltez, Fernando; Santos-Ferreira, Maria Odette




HIV-2 infection and chemokine receptors usage - Clues to reduced virulence of H...

Azevedo-Pereira, JM; Santos-Costa, Q; Moniz-Pereira, J

Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are the causative agents of Acquired Immunodeficiency Syndrome (AIDS). Without therapeutic intervention, HIV-1 or HIV-2 infections in humans are characterized by a gradual and irreversible imm


Functional characterization of the gp105 of primary HIV-2 strains unable to use...

Santos-Costa, Q; Grosso, F; Collman, RG; Moniz-Pereira, J; Azevedo-Pereira, JM


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