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Host-directed therapies based on protease inhibitors to control Mycobacterium t...
Mandal, Manoj; Pires, David; Azevedo-Pereira, Jose Miguel; Anes, ElsaDespite continuous and extensive global efforts in the fight against tuberculosis (TB), this infectious disease continues to exert a tremendous burden on public health concerns and deaths worldwide. TB, caused by the bacterial species Mycobacterium tuberculosis, is highly frequent in people living with HIV. The continuing epidemics of both chronic infections and the emergence of antimicrobial resistance, as wel...
Cystatin F depletion in Mycobacterium tuberculosis-infected macrophages improve...
Mandal, Manoj; Pires, David; Calado, Marta; Azevedo-Pereira, Jose Miguel; Anes, ElsaCystatin F (CstF) is a protease inhibitor of cysteine cathepsins, including those involved in activating the perforin/granzyme cytotoxic pathways. It is targeted at the endolysosomal pathway but can also be secreted to the extracellular milieu or endocytosed by bystander cells. CstF was shown to be significantly increased in tuberculous pleurisy, and during HIV coinfection, pleural fluids display high viral loa...
Molecular Characterization of the env Gene of Two CCR5/CXCR4-Independent Human ...
Santos-Costa, Quirina; Parreira, Ricardo; Moniz-Pereira, Jose; Azevedo-Pereira, Jose MiguelHuman immunodeficiency virus 2 (HIV-2) infection is characterized by a slower disease progression and lower transmission rates. The molecular features that could be assigned as directly involved in this in vivo phenotype remain essentially unknown, and th. - Fundacao para a Ciencia e Tecnologia (FCT) [POCI/SAU-IMI/55726/2004]. - Grant sponsor: Fundacao para a Ciencia e Tecnologia (FCT); Grant number: POCI/SAU-I...