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Comparison of etoricoxib and indomethacin for the treatment of experimental per...

Azoubel, M.C.F.; Menezes, Adriana Magalhães Andrade; Bezerra, Daniel Pereira; Oriá, Reinaldo Barreto; Ribeiro, Ronaldo de Albuquerque

We investigated the effect of etoricoxib, a selective cyclooxygenase- 2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhib- itor, on experimental periodontitis, and compared their gastrointesti- nal side effects. A ligature was placed around the second upper left molars of female Wistar rats (160 to 200 g). Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/...

Date: 2013   |   Origin: Oasisbr
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