81 documents found, page 1 of 9
Red blood cell proteomic profiling in mild and severe obstructive sleep apnea p...
Valentim-Coelho, Cristina; Saraiva, Joana; Osorio, Hugo; Antunes, Marília; Vaz, Fátima; Neves, Sofia; Pinto, Paula; Bárbara, Cristina; Penque, DeborahFunding Information: Project partially supported by Harvard Medical School \u2013 Portugal Program ( HMSPICJ/0022/2011 ), Instituto Nacional de Sa\u00FAde Dr. Ricardo Jorge \u2013 INSA, Centro de Toxicogen\u00F3mica e Sa\u00FAde Humana \u2013 ToxOmics, Rede Nacional de Espectrometria de Massa \u2013 RNEM, FCT /Poly-Annual Funding Program and FEDER /Sa\u00FAde XXI Program, Portugal. Cristina Coelho (SFRH/BD/1335...
Host and environmental determinants of in-hospital mortality in community-acqui...
Pessoa, Ezequiel; Bárbara, Cristina; Costa, Andreia; Nogueira, Paulo JorgeBackground: Community-Acquired Pneumonia (CAP) is regarded as a substantial part of the global burden of disease and a public health priority. In addition to host factors, such as demographic characteristics, comorbidities, CAP clinical severity, and in-hospital mortality may also be influenced by factors such as socioeconomic status, seasonal variations, and hospital differentiation. This study aims to analyse...
Red blood cell proteomic profiling in mild and severe obstructive sleep apnea p...
Valentim-Coelho, Cristina; Saraiva, Joana; Osório, Hugo; Antunes, Marilia; Vaz, Fátima; Neves, Sofia; Pinto, Paula; Bárbara, Cristina; Penque, DeborahObstructive Sleep Apnea (OSA) is characterized by recurrent-episodes of apneas/hypopneas during sleep, leading to recurrent intermittent-hypoxia and sleep fragmentation. Non-treated OSA can result in cardiometabolic diseases. In this study, we applied a shotgun-proteomics strategy to deeper investigate the red blood cell-(RBC) homeostasis regulation in the context of OSA-severity and their response to six month...
In the flow of molecular miniaturized fungal diagnosis
Zolotareva, Maria; Cascalheira, Francisco; Caneiras, Catia; Bárbara, Cristina; Caetano, Diogo Miguel; Teixeira, Miguel CachoThe diagnosis of fungal infections presents several challenges and limitations, stemming from the similarities in symptomatology, diversity of underlying pathogenic species, complexity of fungal biology, and scarcity of rapid, affordable, and point-of-care approaches. In this review, we assess technological advances enabling the conversion of cutting-edge laboratory molecular diagnostic methods to cost-effectiv...
Geographical variation in lung function: results from the multicentric cross-se...
Burney, Peter G. J.; Potts, James; Knox-Brown, Ben; Erhabor, Gregory; Hacene Cherkaski, Hamid; Mortimer, Kevin; Anand, Mahesh PadukudruSpirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV1/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,...
Prevalence of chronic cough, its risk factors and population attributable risk ...
Abozid, Hazim; Patel, Jaymini; Burney, Peter; Hartl, Sylvia; Breyer-Kohansal, Robab; Mortimer, Kevin; Nafees, Asaad A.; Al Ghobain, MohammedBackground: Chronic cough is a common respiratory symptom with an impact on daily activities and quality of life. Global prevalence data are scarce and derive mainly from European and Asian countries and studies with outcomes other than chronic cough. In this study, we aimed to estimate the prevalence of chronic cough across a large number of study sites as well as to identify its main risk factors using a stan...
Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL h...
Bousquet, Jean; Melén, Erik; Haahtela, Tari; Koppelman, Gerard; Togias, Alkis; Valenta, Rudolf; Akdis, Cezmi; Czarlewski, Wienczyslawa; Rothenberg, MarcAsthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...
Patient‐centered digital biomarkers for allergic respiratory diseases and asthm...
Bousquet, Jean; Shamji, Mohamed; Anto, Josep M.; Schünemann, Holger; Canonica, Giorgio Walter; Jutel, Marek; Del Giacco, Stafano; Zuberbier, TorstenBiomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/ or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including m...
Determinants associated with uncontrolled asthma in Portugal: a national popula...
Camarinha, Catarina; Fernandes, Milene; Alarcão, Violeta; Franco, João; Manaças, M. E.; Bárbara, Cristina; Nicola, PauloIntroduction and objectives: Asthma is a chronic and heterogeneous disease that affects people of all ages and has a high estimated increase in prevalence worldwide. Asthma control represents a main goal in the disease management. International studies revealed low levels of disease control resulting in a significant burden for healthcare systems, not only in terms of quality of life, but also in terms of healt...
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDAL...
Bousquet, J.; Melén, E.; Haahtela, T.; Koppelman, G. H.; Togias, A.; Valenta, R.; Akdis, C. A.; Czarlewski, W.; Rothenberg, M.; Valiulis, A.Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...