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European Journal of Heart Failure consensus statement. Heart failure pharmacoth...

Luedde, Mark; Agewall, Stefan; Ambrosio, Giuseppe; Bayes‐Genis, Antoni; Borghi, Claudio; Cerbai, Elisabetta; Dan, Gheorghe A.; Drexel, Heinz

Heart failure (HF) and atrial fibrillation (AF) are major global health challenges with rising prevalence and significant morbidity, mortality, and healthcare burden. Despite advances in HF management, AF remains a critical comorbidity that worsens outcomes and requires ad hoc treatment strategies, increasing the risk of non-adherence and side effects. While rhythm control strategies in AF have gained attention...

Data: 2025   |   Origem: IC-online

Patiromer facilitates angiotensin inhibitor and mineralocorticoid antagonist th...

Pitt, Bertram; Anker, Stefan D.; Lund, Lars H.; Coats, Andrew J. S.; Filippatos, Gerasimos; Rossignol, Patrick; Weir, Matthew R.; Friede, Tim

Background: Hyperkalemia (HK) is associated with suboptimal renin-angiotensin system (RAS) inhibitor and mineralocorticoid receptor antagonist (MRA) use in heart failure with reduced ejection fraction (HFrEF). Objectives: This study sought to assess characteristics and RAS inhibitor/MRA use in patients receiving patiromer during the DIAMOND (Patiromer for the Management of Hyperkalemia in Subjects Receiving RAA...


Patiromer for the management of hyperkalemia in heart failure with reduced ejec...

Butler, Javed; Anker, Stefan D.; Lund, Lars H; Coats, Andrew J. S.; Filippatos, Gerasimos; Siddiqi, Tariq Jamal; Friede, Tim; Fabien, Vincent

Aims: To investigate the impact of patiromer on the serum potassium level and its ability to enable specified target doses of renin-angiotensin-aldosterone system inhibitor (RAASi) use in patients with heart failure and reduced ejection fraction (HFrEF). Methods and results: A total of 1642 patients with HFrEF and current or a history of RAASi-related hyperkalemia were screened and 1195 were enrolled in the run...


Clinical correlates and prognostic impact of neurologic disorders in Takotsubo ...

Cammann, Victoria L.; Scheitz, Jan F.; von Rennenberg, Regina; Jäncke, Lutz; Nolte, Christian H.; Szawan, Konrad A.; Stengl, Helena; Würdinger, Michael

Cardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights rega...


Impact of atrial fibrillation on outcome in Takotsubo syndrome: data from the I...

El‐Battrawy, Ibrahim; Cammann, Victoria L.; Kato, Ken; Szawan, Konrad A.; Di Vece, Davide; Rossi, Aurelio; Wischnewsky, Manfred; Hermes‐Laufer, Julia

Background Atrial fibrillation (AF) is a major risk factor for mortality. The prevalence, clinical correlates, and prognostic impact of AF in Takotsubo syndrome (TTS) have not yet been investigated in a large patient cohort. This study aimed to investigate the prevalence, clinical correlates, and prognostic impact of AF in patients with TTS. Methods and Results Patients with TTS were enrolled from the Internati...


Ethnic comparison in takotsubo syndrome : novel insights from the International...

Imori, Yoichi; Kato, Ken; Cammann, Victoria L.; Szawan, Konrad A.; Wischnewsky, Manfred; Dreiding, Sara; Würdinger, Michael; Schönberger, Maximilian

Background: Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. Methods: TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enr...


Prognostic impact of acute pulmonary triggers in patients with Takotsubo syndro...

Kato, Ken; Cammann, Victoria L.; Napp, L. Christian; Szawan, Konrad A.; Micek, Jozef; Dreiding, Sara; Levinson, Rena A.; Petkova, Vanya

Aims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pu...


Patient profiling in heart failure for tailoring medical therapy: a consensus d...

Rosano, Giuseppe M. C.; Moura, Brenda; Metra, Marco; Böhm, Michael; Bauersachs, Johann; Ben Gal, Tuvia; Adamopoulos, Stamatis; Abdelhamid, Magdy

Despite guideline recommendations and available evidence, implementation of treatment in heart failure (HF) is poor. The majority of patients are not prescribed drugs at target doses that have been proven to positively impact morbidity and mortality. Among others, tolerability issues related to low blood pressure, heart rate, impaired renal function or hyperkalaemia are responsible. Chronic kidney disease plays...


World Heart Federation roadmap on atrial fibrillation : a 2020 update

Freedman, Ben; Hindricks, Gerhard; Banerjee, Amitava; Baranchuk, Adrian; Ching, Chi Keong; Du, Xin; Fitzsimons, Donna; Healey, Jeff S.; Ikeda, Takanori

The World Heart Federation (WHF) commenced a Roadmap initiative in 2015 to reduce the global burden of cardiovascular disease and resultant burgeoning of healthcare costs. Roadmaps provide a blueprint for implementation of priority solutions for the principal cardiovascular diseases leading to death and disability. Atrial fibrillation (AF) is one of these conditions and is an increasing problem due to ageing of...


Coexistence and outcome of coronary artery disease in Takotsubo syndrome

Templin, Christian; Ghadri, Jelena R; Ruschitzka, Frank; Lüscher, Thomas F; Braunwald, Eugene; Bauersachs, Johann; Bax, Jeroen J; Münzel, Thomas

Aims: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a l...


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