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Physical activity, sedentary behaviour, and childhood asthma: a European collab...

Eijkemans, M; Mommers, M; Harskamp-van Ginkel, MW; Vrijkotte, TGM; Ludvigsson, J; Faresjö, Å; Bergström, A; Ekström, S; Grote, V; Koletzko, B

OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined. SETTING: Ch...


Early-life respiratory tract infections and the risk of school-age lower lung f...

van Meel, ER; Mensink-Bout, SM; den Dekker, HT; Ahluwalia, TS; Annesi-Maesano, I; Arshad, SH; Baïz, N; Barros, H; von Berg, A; Bisgaard, H

Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age. Methods We used individual participant data of 150 090 children primarily from the EU Child ...


Biologicals in childhood severe asthma: the European PERMEABLE survey on the st...

Santos-Valente, E; Buntrock-Döpke, H; Abou Taam, R; Arasi, S; Bakirtas, A; Lozano Blasco, J; Bønnelykke, K; Craiu, M; Cutrera, R; Deschildre, A

Introduction: Severe asthma is a rare disease in children, for which three biologicals, anti-immunoglobulin E, anti-interleukin-5 and anti-IL4RA antibodies, are available in European countries. While global guidelines exist on who should receive biologicals, knowledge is lacking on how those guidelines are implemented in real life and which unmet needs exist in the field. In this survey, we aimed to investigate...


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