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Circulating microRNA levels differ in the early stages of insulin resistance in...
Santos, Diana; Porter-Gill, Patricia; Goode, Grace; Delhey, Leanna; Sørensen, Anja Elaine; Rose, Shannon; Børsheim, Elisabet; Dalgaard, Louise TorpAims: The increasing prevalence of childhood obesity escalates the risk for related complications. Circulating microRNAs (miRNAs) have been suggested as good predictive markers of insulin resistance in those with obesity. The aim was to identify a circulating miRNA profile that reflects insulin resistance in prepubertal children with obesity. Material and methods: Plasma miRNAs were measured in prepubertal chil...
Redox Imbalance and Methylation Disturbances in Early Childhood Obesity
Barbosa, Pedro; Melnyk, Stepan; Bennuri, Sirish C; Delhey, Leanna; Reis, Andreia; Moura, Gabriela R; Børsheim, Elisabet; Rose, ShannonObesity is increasing worldwide in prepubertal children, reducing the age of onset of associated comorbidities, including type 2 diabetes. Sulfur-containing amino acids, methionine, cysteine, and their derivatives play important roles in the transmethylation and transsulfuration pathways. Dysregulation of these pathways leads to alterations in the cellular methylation patterns and an imbalanced redox state. The...
Redox imbalance and methylation disturbances in early childhood obesity
Barbosa, Pedro; Melnyk, Stepan; Bennuri, Sirish C.; Delhey, Leanna; Reis, Andreia; Moura, Gabriela R; Børsheim, Elisabet; Rose, ShannonObesity is increasing worldwide in prepubertal children, reducing the age of onset of associated comorbidities, including type 2 diabetes. Sulfur-containing amino acids, methionine, cysteine, and their derivatives play important roles in the transmethylation and transsulfuration pathways. Dysregulation of these pathways leads to alterations in the cellular methylation patterns and an imbalanced redox state. The...
Sulforaphane prevents age-associated cardiac and muscular dysfunction through N...
Bose, Chhanda; Alves, Inês; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; Cheema, Amrita; Boerma, MarjanAge-associated mitochondrial dysfunction and oxidative damage are primary causes for multiple health problems including sarcopenia and cardiovascular disease (CVD). Though the role of Nrf2, a transcription factor that regulates cytoprotective gene expression, in myopathy remains poorly defined, it has shown beneficial properties in both sarcopenia and CVD. Sulforaphane (SFN), a natural compound Nrf2-related act...
Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula ...
Carvalho, Eugenia; Adams, Sean H; Børsheim, Elisabet; Blackburn, Michael L; Ono-Moore, Kikumi D; Cotter, Matthew; Bowlin, Anne K; Yeruva, LaxmiBackground: Neonatal diet impacts many physiological systems and can modify risk for developing metabolic disease and obesity later in life. Less well studied is the effect of postnatal diet (e.g., comparing human milk (HM) or milk formula (MF) feeding) on mitochondrial bioenergetics. Such effects may be most profound in splanchnic tissues that would have early exposure to diet-associated or gut microbe-derived...
Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Su...
Marquis, Bryce J; Hurren, Nicholas M; Carvalho, Eugenia; Kim, Il-Young; Schutzler, Scott; Azhar, Gohar; Wolfe, Robert R; Børsheim, ElisabetBackground: Supplementation with essential amino acids (EAAs) + arginine is a promising nutritional approach to decrease plasma triglyceride (TG) concentrations, which are an independent risk factor for ischemic heart disease. Objective: The objective of this study was to examine the effects of 8 wk of EAA supplementation on skeletal muscle basal metabolite concentrations and changes in metabolic response to ac...
The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing
Moura, João; Børsheim, Elisabet; Carvalho, EugeniaOverweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the most important complications include macrovascular abnormalities, e.g., heart disease and atherosc...