17 documents found, page 1 of 2

SARS-CoV-2 Infection in Children

Children with COVID-19 typically experience milder symptoms and lower hospitalization rates, though severe cases do occur. Understanding age-related immune responses is crucial for future preparedness. We characterized immune response dynamics to SARS-CoV-2 in 145 samples from 119 pediatric patients (<18 years) with confirmed infection, assessed at four distinct time points: <14 days, 14 days-3 months, 3-6 mont...

Cytokine Dynamics in Acute Pancreatitis

Background: Acute pancreatitis (AP) is an inflammatory disease of the pancreas with incompletely known pathogenic mechanisms. This study aimed to explore the temporal changes in serum cytokines in patients with AP and to assess the association of these changes with disease severity. Methods: Fifty patients hospitalized with AP were enrolled, and their serum cytokine levels were analyzed at four different time p...

Building a Better Defense

Funding Information: This work was funded by the Fundação da Ciência e Tecnologia (FCT) with reference number SFRH/BD/144965/2019 and by the European Hematology Association (EHA) Research Mobility Grant 2023. Publisher Copyright: © 2024 by the authors.; Natural killer (NK) cells have gained attention as a promising adoptive cell therapy platform for their potential to improve cancer treatments. NK cells offer d...

B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatit...

Funding Information: This research was funded by the Learning Health Hospital da Luz. LH.INV.F2019002. Publisher Copyright: © 2024 by the authors.; Acute pancreatitis (AP) is an increasingly frequent disease in which inflammation plays a crucial role. Fifty patients hospitalized with AP were included and peripheral blood samples were analyzed for B and T cell subpopulations at the time of hospitalization and 48...

The Role of NK and T Cells in Endometriosis

Endometriosis, a debilitating condition, affects one in ten women of reproductive age. Its pathophysiology remains unclear, though deficiencies in immune surveillance are thought to create an environment conducive to the evasion of ectopic endometrial cells from the immune system. Our research explores the immunological impact of endometriosis both locally and systemically, emphasizing natural killer (NK) and T...

Polythylene glycol severe allergy and SARS-CoV-2 vaccines

Background. Polyethylene glycol (PEG) is being used for first time as an excipient for mRNA anti-SARS-CoV-2 vaccines containing-PEG2000, highlighting it as a potential cause of anaphylaxis. Objective. To assess the usefulness of skin tests using PEG1500 extract in patients with suspected allergy to SARS-CoV-2 vaccines. Methods. We evaluated 126 patients with moderate-high risk of allergy to SARS-CoV-2 vaccines ...

Added value of lymphocyte subpopulations in the classification of Sjögren's syn...

Funding Information: The first author gratefully acknowledges Academia Cuf/José de Mello Saúde and Sociedade Portuguesa de Reumatologia for their financial support. The authors gratefully acknowledge the laboratory staff that assisted in the flow cytometry analysis. Publisher Copyright: © 2023, The Author(s).; Sjögren's Syndrome (SjS) is a chronic systemic immune-mediated inflammatory disease characterized by l...

Anaphylactic shock to iodinated contrast media

Audiological biomarkers of tinnitus in an older Portuguese population

Funding: HH and DR had received a Ph.D. grant from Jmellosaude. DH was funded by the National Institute for Health Research (NIHR) Biomedical Research Centre program. The present publication was funded by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020).; Tinnitus is a phantom sound perceived in the absence of external acoustic stimulation. It is described in a variety of ways (...

Association between EBV serological patterns and lymphocytic profile of SjS pat...

Sjögren's syndrome (SjS) is characterized by lymphocytic infiltration of exocrine glands, i.e. autoimmune epithelitis. Lymphocytes are central in SjS pathogenesis, with B-cell hyperactivity mediated by T-cells. B-cells are main targets of Epstein-Barr virus (EBV) infection, a frequently-suggested trigger for SjS. We aimed to evaluate how the EBV infection modulates B and T-cell subsets in SjS, including as cont...