6 documents found, page 1 of 1
The global gastric cancer consortium: an update from the Stomach cancer Pooling...
Pelucchi, C; La Vecchia, C; Bonzi, R; Negri, E; Corso, G; Boccia, S; Boffetta, P; Camargo, MC; Curado, MP; Lunet, N; Vioque, J; Zhang, ZFWe updated to December 2023 the main findings of the stomach cancer pooling (StoP) project including about 13 000 cases and 31 000 controls from 29 case–control and 5 nested studies. The StoP project quantified more precisely than previously available the positive associations of tobacco smoking, high alcohol consumption, meat intake, selected occupations (e.g. agricultural and miners), gastric ulcer and family...
Geographical distribution of e-cadherin germline mutations in the context of di...
Corso, G; Corso, F; Bellerba, F; Carneiro, P; Seixas, S; Cioffi, A; La Vecchia, C; Magnoni, F; Bonanni, B; Veronesi, P; Gandini, S; Figueiredo, JHereditary diffuse gastric cancer (HDGC) is a complex and multifactorial inherited cancer predisposition syndrome caused by CDH1 germline mutations. Nevertheless, current CDH1 genetic screening recommendations disregard an unbalanced worldwide distribution of CDH1 variants, impacting testing efficacy and patient management. In this systematic review, we collected and analyzed all studies describing CDH1 variant...
Hereditary gastric and breast cancer syndromes related to CDH1 germline mutatio...
Corso, G; Montagna, G; Figueiredo, J; Vecchia, CL; Romario, UF; Fernandes, MS; Seixas, S; Roviello, F; Trovato, C; Guerini-Rocco, E; Fusco, NE-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an inherited predisposition of lobular breast carcinoma. In 2019, the international gastric cancer linkage consortium revised the clinical criteria and established guidelines for the genetic screening of CDH1 germline syndromes. Nev...
E-cadherin deregulation in breast cancer
Corso, G; Figueiredo, J; Angelis, SP; Corso, F; Girardi, A; Pereira, J; Seruca, R; Bonanni, B; Carneiro, P; Pravettoni, G; Guerini Rocco, E; Veronesi, PE-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a pro...
Recomendações para o Diagnóstico e Tratamento do Adenocarcinoma Gástrico (Grupo...
Brito, D; Raimundo, A; Sousa, O; Pereira, H; Ribau, E; Afonso, LP; Cabral, S; Dinis-Ribeiro, M; Nogueira, C; Barroso, S; Bettencourt, A; Gíria, J
Somatic mutations and deletions of the E-cadherin gene predict poor survival of...
Corso, G; Carvalho, J; Marrelli, D; Vindigni, C; Carvalho, B; Seruca, R; Roviello, F; Oliveira, CPurpose The prognosis of gastric cancer (GC) is poor, and the molecular pathogenesis players are vastly unknown. Surgery remains the primary option in GC treatment. The aim of this study was to investigate the impact of somatic CDH1 alterations in prognosis and survival of patients with GC. Patients and Methods A series of patients with sporadic and familial GC (diffuse and intestinal; n _ 246) were analyzed fo...