34 documents found, page 1 of 4
Evaluation of feline permanent canine tooth mineral density using micro-compute...
Silva, Graça; Babo, Pedro Miguel Sousa; Azevedo, Jorge; Gomes, Manuela E.; Viegas, Carlos; Requicha, João F.The tooth is made up of three mineralized tissues, enamel, dentin, and cementum, which surround a non-mineralized tissue called the dental pulp. Micro-computed tomography (mCT) is an imaging technology based on X-rays that allows non-invasive visualization of objects at a microscopic scale, according to their radiopacity and in three dimensions (3D). Likewise, it allows the subsequent execution of morphological...
Development and characterization of highly stable silver nanoparticles as novel...
Massironi, Alessio; Franco, Albina Ribeiro; Babo, Pedro Miguel Sousa; Puppi, Dario; Chiellini, Federica; Reis, R. L.; Gomes, Manuela E.Recurrent microbial infections are a major cause of surgical failure and morbidity. Wound healing strategies based on hydrogels have been proposed to provide at once a barrier against pathogen microbial colonization, as well as a favorable environment for tissue repair. Nevertheless, most biocompatible hydrogel materials are more bacteriostatic than antimicrobial materials, and lack specific action against path...
Evaluation of injectable hyaluronic acid-based hydrogels for endodontic tissue ...
Astudillo-Ortiz, Esteban; Babo, Pedro Miguel Sousa; Reis, R. L.; Gomes, Manuela E.Dental pulp tissue engineering (TE) endeavors to regenerate dentin/pulp complex by combining a suitable supporting matrix, stem cells, and biochemical stimuli. Such procedures foresee a matrix that can be easily introduced into the root canal system (RCS) and tightly adhere to dentin walls to assure the dentin surface’s proper colonization with progenitor cells capable of restoring the dentin/pulp complex. Here...
Hyaluronic acid oligomer immobilization as an angiogenic trigger for the neovas...
Silva, A. L.; Babo, Pedro Miguel Sousa; Rodrigues, Márcia T.; Gonçalves, A I; Novoa-Carballal, Ramon; Pires, R. A.; Rouwkema, J.; Reis, R. L.Tissue engineered (TE) substitutes of clinically relevant sizes need an adequate vascular system to ensure function and proper tissue integration after implantation. However, the predictable vascularization of TE substitutes is yet to be achieved. Molecular weight variations in hyaluronic acid (HA) have been pointed to trigger angiogenesis. Thus, this study investigates HA oligomer immobilization as a promoter ...
Supplementary solvent irrigation efficacy on filling remnants removal comparing...
Ferreira, Inês; Babo, Pedro Miguel Sousa; Braga, A. C.; Lopes, Maria Ascensão; Gomes, Manuela E.; Pina-Vaz, IreneThis study aimed to compare the efcacy of XP-endo Finisher R and IrriSafe, with a solvent mixture of Methyl ethyl ketone/Tetrachloroethylene (MEK/TCE), in the removal of root flling residues. Twentyfour human mandibular incisors were pair-matched by micro-computed tomography according to volume and aspect ratio. After retreatment, specimens were allocated to two experimental groups (n= 12), according to the sup...
Platelet-derived products in veterinary medicine: A new trend or an effective t...
Soares, Carla S.; Babo, Pedro Miguel Sousa; Reis, R. L.; Carvalho, P. P.; Gomes, Manuela E.Platelet-derived products (PDPs) have gained popularity, mainly due to their high concentrations of bioactive molecules such as growth factors and cytokines, which play important roles in tissue healing and regeneration. PDPs are obtained through minimally invasive procedures and their therapeutic effect has been widely recognized. In veterinary medicine, however, the lack of standard protocols to generate PDPs...
Platelet-rich blood derivatives for tendon regeneration
Almeida, Raquel Costa; Babo, Pedro Miguel Sousa; Reis, R. L.; Gomes, Manuela E.Tendon injuries constitute a significant healthcare problem with variable clinical outcomes. The complex interplay of tissue homeostasis, degeneration, repair, and regeneration makes the development of successful delivery therapeutic strategies challenging. Platelet-rich hemoderivatives, a source of supra-physiologic concentrations of human therapeutic factors, are a promising application to treat tendon injuri...
Epitope‐imprinted nanoparticles as transforming growth factor‐β3 sequestering l...
Teixeira S. P. B.; Domingues, R. M. A.; Babo, Pedro Miguel Sousa; Berdecka, D.; Miranda, Margarida Silva; Gomes, Manuela E.; Peppas, N. A.; Reis, R. L.Growth factors (GFs) are biomolecules with potent biological effects but inherent limitations hinder their potential as therapeutic agents and cell culture supplements in tissue engineering and regenerative medicine (TERM). Biomaterials that sequester endogenous GFs by affinity binding might circumvent such limitations and thus are being increasingly investigated. Here, molecularly imprinted nanoparticles (MINP...
Bioinspired materials and tissue engineering approaches applied to the regenera...
Rodrigues, Márcia T.; Gonçalves, A I; Babo, Pedro Miguel Sousa; Gomez-Florit, Manuel; Reis, R. L.; Gomes, Manuela E.The musculoskeletal tissues have a prime role in the biomechanical support and metabolic activities of the human body. As musculoskeletal tissues are highly prone to injuries, conditions afflicting these tissues have a great impact on the quality of life of patients worldwide. Tissue engineering approaches hold the promise to develop bioengineered substitutes aiming at the regeneration of failing and injured ti...
Evaluation of hematology, general serum biochemistry, bone turnover markers and...
Coelho, Catarina A.; Bordelo, João P.; Camassa, José A.; Barros, Vera A.; Babo, Pedro Miguel Sousa; Gomes, Manuela E.; Reis, R. L.; Azevedo, J. T.Osteoporosis is a metabolic disorder characterized by a loss of bone mass and structure and increasing the risk of fragility fractures, mostly among postmenopausal women. Sheep is a recognized large animal model for osteoporosis research. An experimental group of ewes (3-4 years old) was subjected to ovariectomy (OVX) and weekly glucocorticoid (GC) application for 24 weeks and compared with a sham control group...