12 documents found, page 1 of 2
Association of enzymatic and optimized ultrasound-assisted aqueous extraction o...
Nicolescu, Alexandru; Babotă, Mihai; Aranda Cañada, Eduardo; Dias, Maria Inês; Añibarro-Ortega, Mikel; Cornea-Cipcigan, Mihaiela; Tanase, CorneliuThe main purpose of the present study was to determine the effect of associating an optimized ultrasound-assisted extraction (UAE) protocol with enzyme-assisted extraction (EAE) in aqueous media, using the dried berries of Hippophae rhamnoides L. (sea buckthorn) as plant material. A specialized software was used for the determination of potential optimal extraction parameters, leading to the development of four...
Bioaccessibility and bioactive potential of different phytochemical classes fro...
Nicolescu, Alexandru; Babotă, Mihai; Barros, Lillian; Lucini, Luigi; Tanase, Corneliu; Mocan, Andrei; Bunea, Claudiu I.; Crisan, GianinaNutraceuticals and functional foods are composed of especially complex matrices, with polyphenols, carotenoids, minerals, and vitamins, among others, being the main classes of phytochemicals involved in their bioactivities. Despite their wide use, further investigations are needed to certify the proper release of these phytochemicals into the gastrointestinal medium, where the bioaccessibility assay is one of t...
Thymus species from romanian spontaneous flora as promising source of phenolic ...
Babotă, Mihai; Frumuzachi, Oleg; Mafra, Isabel; Nicolescu, Alexandru; Dias, Maria Inês; Pinela, José; Barros, Lillian; Añibarro-Ortega, MikelWild thyme aerial parts (Serpylli herba) are recognized as a valuable herbal product with antioxidant, anti-inflammatory, and antibacterial effects. Although pharmacopoeial regulations allow its collection exclusively from Thymus serpyllum, substitution with other species is frequent in current practice. This study analyzed the phenolic composition, antioxidant, and enzyme-inhibitory and antimicrobial activity ...
Untargeted phytochemical profiling and biological activity of small yellow onio...
Moldovan, Cadmiel; Frumuzachi, Oleg; Babotă, Mihai; Pinela, José; Barros, Lillian; Rocchetti, Gabriele; López, Víctor; Lucini, Luigi; Crisan, GianinaThis study examined the phytochemical profiles (mainly phenolics, carotenoids, and organosulfur compounds) and biological effects of hydroalcoholic extracts of Allium flavum (AF), a species of the Allium genus commonly known as small yellow onion. Unsupervised and supervised statistical approaches revealed clear differences between extracts prepared with samples collected from different areas of Romania. Overal...
Unravelling phytochemical and bioactive potential of three hypericum species fr...
Babotă, Mihai; Frumuzachi, Oleg; Mocan, Andrei; Tamas, Mircea; Dias, Maria Inês; Pinela, José; Stojković, Dejan; Soković, MarinaHypericum perforatum L., also known as St. John's Wort, is recognized worldwide as a valuable medicinal herb; however, other Hypericum species were intensively studied for their bioactive potential. To fill the research gap that exists in the scientific literature, a comparative evaluation between H. alpigenum Kit., H. perforatum L. and H. rochelii Griseb. & Schenk was conducted in the present study. Two types ...
Bioactive compounds and functional properties of herbal preparations of Cystus ...
Mocan, Andrei; Fernandes, Ângela; Calhelha, Ricardo C.; Gavrilas, Laura; Ferreira, Isabel C.F.R.; Ivanov, Marija; Barros, Lillian; Babotă, MihaiThe members of Cystus genus are perenial shrubs with a well-established use in traditional medicine. Among these, C. creticus is the most popular, herbal preparations obtained from its aerial parts being recognized as antimicrobial, antitumor and anti-inflammatory agents. The present study aimed to evaluate phytochemical profile and bioactive potential of aqueous and hydroethanolic extracts of C. creticus aeria...
Therapeutic uses and pharmacological properties of shallot (Allium ascalonicum)...
Moldovan, Cadmiel; Frumuzachi, Oleg; Babotă, Mihai; Barros, Lillian; Mocan, Andrei; Carradori, Simone; Crisan, GianinaBackgroundShallot (Allium ascalonicum L.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts. Scope and ApproachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigor...
Potential therapeutic applications of infusions and hydroalcoholic extracts of ...
Nicolescu, Alexandru; Babotă, Mihai; Ilea, Maria; Dias, Maria Inês; Calhelha, Ricardo C.; Gavrilaș, Laura; Rocchetti, Gabriele; Crişan, GianinaEthnopharmacological relevance: Salvia glutinosa, also known as the glutinous sage, has been used in Romanian folk medicine in the treatment of inflammation, injuries, and mild infections. However, there is no direct scientific evidence to demonstrate these activities. Aim of the Study: The present research was based on evaluating antioxidant, antiproliferative, and α-glucosidase inhibitory activity of S. gluti...
Optimized ultrasound-assisted extraction of phenolic compounds from Thymus como...
Babotă, Mihai; Frumuzachi, Oleg; Gâvan, Alexandru; Iacoviță, Cristian; Pinela, José; Barros, Lillian; Ferreira, Isabel C.F.R.; Zhang, LeileiAn optimized ultrasound-assisted extractive method was developed to obtain a polyphenol-enriched extract from the aerial parts of Thymus comosus Heuff. ex Griseb. et Schenk. Optimization process was conducted based on Design of Experiment (DoE) principles, determining the influence of three independent variables (time, ultrasound amplitude, ethanol concentration) on the total phenolic content of the extract (de...
Chemical composition, diuretic, and antityrosinase activity of traditionally us...
Babotă, Mihai; Voştinaru, Oliviu; Păltinean, Ramona; Mihali, Cosmin; Dias, Maria Inês; Barros, Lillian; Ferreira, Isabel C.F.R.; Mocan, AndreiCherry stems (CS) represent a by-product intensively used in Eastern European countries as a traditional remedy for urinary tract disorders. Ethnopharmacological evidences sustain the use of CS as aqueous preparations (infusion and decoction), but few data were previously reported about phytochemical profile and pharmacological potential of CS hydroalcoholic extracts. In this regard, we aimed to evaluate the ph...